GADD34 Antibody – Goat Polyclonal

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]

GADD34: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Belongs to the PPP1R15 family.

Protein type: Apoptosis; Translation initiation; DNA repair, damage; Cell cycle regulation

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; mitochondrial outer membrane; membrane; mitochondrion; endoplasmic reticulum; cytoplasm; protein phosphatase type 1 complex; cytosol

Molecular Function: protein binding; protein phosphatase type 1 regulator activity; protein kinase binding; protein phosphatase 1 binding

Biological Process: negative regulation of protein amino acid dephosphorylation; positive regulation of phosphoprotein phosphatase activity; apoptosis; unfolded protein response; transforming growth factor beta receptor signaling pathway; negative regulation of phosphoprotein phosphatase activity; positive regulation of translation initiation in response to stress; cell cycle arrest; negative regulation of transforming growth factor beta receptor signaling pathway; response to DNA damage stimulus; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase I promoter