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IP-10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS221720

Rabbit anti Human IP-10 antibody recognizes human IP-10 (10-kDa interferon-inducible protein), otherwise known as CXCL10, a 77 amino acid CXC chemokine which, like monokine induced by IFN-gamma (Mig) and IFN-inducible T-cell alpha-chemoattractant (I-TAC),… More details

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Product Overview

Product Name
IP-10, Polyclonal Antibody
Full Product Name
RABBIT ANTI HUMAN IP-10
Product Gene Name
anti-IP-10 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Purified
Purified IgG - lyophilised
Concentration
IgG concentration 1.0 mg/ml after reconstitution (lot specific)
Preparation and Storage
Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
Molecular Weight
10,881 Da
OMIM
147310
3D Structure
ModBase 3D Structure for P02778
Reconstitution
Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended. NB: For functional studies do not add azide.
Immunogen
Recombinant human IP-10
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to human IP-10 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-IP-10 antibody
ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB)
Application Notes for anti-IP-10 antibody
ELISA: This purified human IP-10 antibody may be used in an indirect ELISA or as the capture reagent in a sandwich ELISA with our biotinylated human IP-10 antibody as the detection antibody
ELISA: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml
Immunohistology - Paraffin: Minimum Dilution: 1.0ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml

Testing Data #1 of anti-IP-10 antibody

Formalin fixed, paraffin embedded human carcinoid tissue stained with Rabbit anti Human IP-10 (MBS221720) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Rabbit Anti-IP-10 Polyclonal Antibody – Cat# MBS221720

Testing Data #2 of anti-IP-10 antibody

Formalin fixed, paraffin embedded human carcinoid tissue stained with Rabbit anti Human IP-10 (MBS221720) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Rabbit Anti-IP-10 Polyclonal Antibody, Testing Data #2 – Cat# MBS221720

Testing Data #3 of anti-IP-10 antibody

Formalin fixed, paraffin embedded human carcinoid tissue stained with Rabbit anti Human IP-10 (MBS221720) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Rabbit Anti-IP-10 Polyclonal Antibody, Testing Data #3 – Cat# MBS221720

Testing Data #4 of anti-IP-10 antibody

Formalin fixed, paraffin embedded human carcinoid tissue stained with Rabbit anti Human IP-10 (MBS221720) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Rabbit Anti-IP-10 Polyclonal Antibody, Testing Data #4 – Cat# MBS221720

Other Notes

Small volumes of anti-IP-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IP-10 purchase

MBS221720 is an antibody targeting IP-10. Also known as RABBIT ANTI HUMAN IP-10. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IP-10. It may not necessarily be applicable to this product.

NCBI GI #
149999382
NCBI GeneID
3627
NCBI Accession #
NP_001556.2
UniProt Primary Accession #
P02778
UniProt Secondary Accession #
Q96QJ5
UniProt Related Accession #
P02778
GenBank Nucleotide #
NM_001565.3
NCBI Official Full Name
C-X-C motif chemokine 10
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 10
NCBI Official Symbol
CXCL10
NCBI Official Synonym Symbols
C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
UniProt Protein Name
C-X-C motif chemokine 10
UniProt Synonym Protein Names
10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10CXCL10(1-73)
UniProt Gene Name
CXCL10
UniProt Synonym Gene Names
INP10; SCYB10; Gamma-IP10; IP-10
UniProt Entry Name
CXL10_HUMAN
NCBI Protein Information
C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; gamma IP10; gamma-IP10; interferon-inducible cytokine IP-10; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10; small-inducible cytokine B10

NCBI Summary for IP-10

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]
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UniProt Comments for IP-10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity; cAMP-dependent protein kinase regulator activity; receptor binding

Biological Process: muscle development; blood circulation; protein secretion; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; chemotaxis; signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; response to vitamin D; cell surface receptor linked signal transduction; cell-cell signaling; positive regulation of cell proliferation; response to gamma radiation; positive regulation of transcription from RNA polymerase II promoter; immune response; response to cold; positive regulation of release of sequestered calcium ion into cytosol; regulation of protein kinase activity; negative regulation of myoblast differentiation; inflammatory response; defense response to virus
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Research Articles on IP-10

1. Serum IP-10 and NGAL have demonstrated good predictive ability for the development of acute kidney graft rejection at a very early time point.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IP-10 antibody

 Reference Product  PubMed Publications
 CXCL9 antibody  >905 publications with IP-10 and CXCL9
 CXCR3 antibody  >827 publications with IP-10 and CXCR3
 CCL5 antibody  >641 publications with IP-10 and CCL5
 CXCL11 antibody  >461 publications with IP-10 and CXCL11
 CCR5 antibody  >174 publications with IP-10 and CCR5
 CCL20 antibody  >108 publications with IP-10 and CCL20
 CCL11 antibody  >101 publications with IP-10 and CCL11
 CXCR2 antibody  >50 publications with IP-10 and CXCR2
 CCR1 antibody  >47 publications with IP-10 and CCR1
 CCR3 antibody  >47 publications with IP-10 and CCR3

Pathways associated with anti-IP-10 antibody

 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram

Diseases associated with anti-IP-10 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1158 publications with IP-10 and Inflammation
 Necrosis Antibodies  >668 publications with IP-10 and Necrosis
 Disease Models, Animal Antibodies  >337 publications with IP-10 and Disease Models, Animal
 Lung Diseases Antibodies  >332 publications with IP-10 and Lung Diseases
 Liver Diseases Antibodies  >229 publications with IP-10 and Liver Diseases
 Cardiovascular Diseases Antibodies  >169 publications with IP-10 and Cardiovascular Diseases
 Fibrosis Antibodies  >126 publications with IP-10 and Fibrosis
 Neoplasms, Experimental Antibodies  >113 publications with IP-10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >86 publications with IP-10 and Kidney Diseases
 Lung Injury Antibodies  >63 publications with IP-10 and Lung Injury

Organs/Tissues associated with anti-IP-10 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2016 publications with IP-10 and Blood
 Lung Antibodies  >446 publications with IP-10 and Lung
 Liver Antibodies  >265 publications with IP-10 and Liver
 Kidney Antibodies  >178 publications with IP-10 and Kidney
 Lymph Node Antibodies  >159 publications with IP-10 and Lymph Node
 Muscle Antibodies  >119 publications with IP-10 and Muscle
 Intestine Antibodies  >90 publications with IP-10 and Intestine
 Nerve Antibodies  >60 publications with IP-10 and Nerve
 Uterus Antibodies  >33 publications with IP-10 and Uterus
 Placenta Antibodies  >27 publications with IP-10 and Placenta
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