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SARM1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150071

MBS150071 is an antibody targeting SARM1. Also known as SARM Antibody. Reactive in Human, Mouse. Host: Rabbit. More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SARM (SARM1), Polyclonal Antibody
Full Product Name
SARM Antibody
Product Gene Name
anti-SARM1 antibody
Product Synonym Names
SARM; SARM; SAMD2; MyD88-5; KIAA0524; SARM; Sterile alpha and TIR motif-containing protein 1; Sterile alpha and Armadillo repeat protein; sterile alpha and TIR motif containing 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
SARM Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
Antibody can be stored at 4 degree C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
SARM peptide (MBS151771) is used for blocking the activity of SARM antibody (MBS150071)
Molecular Weight
Predicted MW: 80 kDa
Observed MW: 85kDa
OMIM
607732
3D Structure
ModBase 3D Structure for Q6SZW1
Immunogen
SARM antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human SARM.
The immunogen is located within amino acids 640-690 of SARM.
Buffer
SARM Antibody is supplied in PBS containing 0.02% sodium azide.
Homology
Predicted species reactivity based on immunogen sequence: Pig: (86%)
Applications Tested/Suitable for anti-SARM1 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-SARM1 antibody
SARM antibody can be used for detection of SARM by Western blot at 0.5 to 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 2 mug/mL. For immunofluorescence start at 2 mug/mL.
Optimal dilutions / concentration for each application to be determined by the researcher.

Western Blot (WB) of anti-SARM1 antibody

Western blot analysis of SARM in Daudi cell lysate with SARM antibody at (A) 0.5 and (B) 1 μg/mL.
Rabbit Anti-SARM1 Polyclonal Antibody – Cat# MBS150071

Immunocytochemistry (IHC) of anti-SARM1 antibody

Immunocytochemistry staining of Daudi cells using SARM antibody at 2 μg/mL.
Rabbit Anti-SARM1 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS150071

Immunofluorescence (IF) of anti-SARM1 antibody

Immunofluorescence of SARM in Daudi cells with SARM antibody at 2 μg/mL.
Rabbit Anti-SARM1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150071

Other Notes

Small volumes of anti-SARM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SARM1. It may not necessarily be applicable to this product.

NCBI GI #
154090976
NCBI GeneID
23098
NCBI Accession #
NP_055892
UniProt Primary Accession #
Q6SZW1
UniProt Secondary Accession #
O60277; Q7LGG3; Q9NXY5
UniProt Related Accession #
Q6SZW1
GenBank Nucleotide #
NM_015077.3
NCBI Official Full Name
sterile alpha and TIR motif-containing protein 1
NCBI Official Synonym Full Names
sterile alpha and TIR motif containing 1
NCBI Official Symbol
SARM1
NCBI Official Synonym Symbols
SARM; SAMD2; MyD88-5
UniProt Protein Name
Sterile alpha and TIR motif-containing protein 1
UniProt Synonym Protein Names
Sterile alpha and Armadillo repeat protein; Sterile alpha motif domain-containing protein 2; MyD88-5; SAM domain-containing protein 2; Tir-1 homolog
Protein Family
Sterile alpha and TIR motif-containing protein
UniProt Gene Name
SARM1
UniProt Synonym Gene Names
KIAA0524; SAMD2; SARM; MyD88-5; SAM domain-containing protein 2
UniProt Entry Name
SARM1_HUMAN
NCBI Protein Information
sterile alpha and TIR motif-containing protein 1; tir-1 homolog; SAM domain-containing protein 2; sterile alpha and Armadillo repeat protein; sterile alpha motif domain-containing protein 2; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila

UniProt Comments for SARM1

SARM1: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q11

Cellular Component: microtubule; mitochondrion; axon; cytoplasm; dendrite; extrinsic to mitochondrial outer membrane; synapse; cytosol; cell junction

Biological Process: regulation of apoptosis; MyD88-independent toll-like receptor signaling pathway; regulation of dendrite morphogenesis; response to glucose stimulus; toll-like receptor signaling pathway; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway
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Research Articles on SARM1

1. These results indicate that association of PINK1 with SARM1 and TRAF6 is an important step for mitophagy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SARM1 antibody

 Reference Product  PubMed Publications
 MYD88 antibody  >16 publications with SARM1 and MYD88
 TICAM1 antibody  >10 publications with SARM1 and TICAM1
 TICAM2 antibody  >7 publications with SARM1 and TICAM2
 RS1 antibody  >1 publications with SARM1 and RS1

Pathways associated with anti-SARM1 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 IKK Complex Recruitment Mediated By RIP1 Pathway antibodies  IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88-independent Cascade Pathway antibodies  MyD88-independent Cascade Pathway Diagram
 TRAF6 Mediated Induction Of TAK1 Complex Pathway antibodies  TRAF6 Mediated Induction Of TAK1 Complex Pathway Diagram
 TRIF-mediated TLR3/TLR4 Signaling Pathway antibodies  TRIF-mediated TLR3/TLR4 Signaling Pathway Diagram
 Toll Like Receptor 3 (TLR3) Cascade Pathway antibodies  Toll Like Receptor 3 (TLR3) Cascade Pathway Diagram
 Toll Like Receptor 4 (TLR4) Cascade Pathway antibodies  Toll Like Receptor 4 (TLR4) Cascade Pathway Diagram

Diseases associated with anti-SARM1 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >11 publications with SARM1 and Death
 Inflammation Antibodies  >5 publications with SARM1 and Inflammation
 Necrosis Antibodies  >3 publications with SARM1 and Necrosis
 Kidney Diseases Antibodies  >1 publications with SARM1 and Kidney Diseases
 Cognition Disorders Antibodies  >1 publications with SARM1 and Cognition Disorders

Organs/Tissues associated with anti-SARM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with SARM1 and Brain
 Kidney Antibodies  >5 publications with SARM1 and Kidney
 Eye Antibodies  >3 publications with SARM1 and Eye
 Ganglia Antibodies  >2 publications with SARM1 and Ganglia
 Intestine Antibodies  >1 publications with SARM1 and Intestine
 Spleen Antibodies  >1 publications with SARM1 and Spleen
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