Rabbit Anti-GAP43 Polyclonal Antibody – Cat# MBS221792

GAP43 Antibody – Rabbit Polyclonal

Name: GAP43 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS221792
Price: 740 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS221792

MBS221792 is specific for Growth Associated Peptide 43 (GAP-43), when phosphorylated at serine 41. GAP-43 is expressed in neuronal growth cones during development and during axonal regeneration and is phosphorylated at Ser41 by protein kinase C. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GAP43, Polyclonal Antibody

Full Product Name

RABBIT ANTI GAP43 (pSer41)

Product Gene Name

anti-GAP43 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Bovine (Expected from Sequence), Chicken (Expected from Sequence), Dog (Expected from Sequence), Human (Expected from Sequence), Monkey (Expected from Sequence), Mouse (Expected from Sequence), Xenopus (Expected from Sequence), Zebrafish (Expected from Se

Form/Format

Purified
Purified IgG - liquid

Specificity

This item is specific for Growth Associated Peptide 43 (GAP-43), when phosphorylated at serine 41.

GAP-43 is expressed in neuronal growth cones during development and during axonal regeneration and is phosphorylated at Ser41 by protein kinase C.

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.

Molecular Weight

28,766 Da

OMIM

162060

3D Structure

ModBase 3D Structure for P17677

Perservative Stabilisers

0.09% Sodium Azide
0.01% Bovine Serum Albumin
50% Glycerol

Immunogen

Synthetic phosphopeptide corresponding to an amino acid sequence within GAP-43 which includes phosphorylated Ser41.
Buffer Solution||10mM HEPES pH7.5

Antiserum Preparation

Antisera to phosphorylated GAP-43 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Target Species

Rat

Applications Tested/Suitable for anti-GAP43 antibody

Western Blot (WB)*

Application Notes for anti-GAP43 antibody

Western Blot: This item detects a band of approximately 50kDa in rat cortex lysates.
Western Blotting: Maximum Dilution: 1/1000; Application Note: For the detection of phosphoproteins, serine phosphatase inhibitors such as 10mM Sodium Fluoride should be added to the sample buffer. Milk or other casein-based blocking solutions are not recommended as casein is a phosphoprotein and its use can result in high background.

Other Notes

Small volumes of anti-GAP43 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GAP43 purchase

MBS221792 is an antibody targeting GAP43. Also known as RABBIT ANTI GAP43 (pSer41). Reactive in Bovine (Expected from Sequence), Chicken (Expected from Sequence), Dog (Expected from Sequence), Human (Expected from Sequence), Monkey (Expected from Sequence), Mouse (Expected from Sequence), Xenopus (Expected from Sequence), Zebrafish (Expected from Se. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GAP43. It may not necessarily be applicable to this product.

NCBI GI #

194248057

NCBI GeneID

2596

NCBI Accession #

NP_001123536.1

UniProt Primary Accession #

P17677

UniProt Secondary Accession #

A8K0Y4

UniProt Related Accession #

P17677

GenBank Nucleotide #

NM_001130064.1

NCBI Official Full Name

neuromodulin isoform 1

NCBI Official Synonym Full Names

growth associated protein 43

NCBI Official Symbol

GAP43

NCBI Official Synonym Symbols

B-50; PP46

UniProt Protein Name

Neuromodulin

UniProt Synonym Protein Names

Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46

Protein Family

Neuromodulin

UniProt Gene Name

GAP43

UniProt Entry Name

NEUM_HUMAN

NCBI Protein Information

neuromodulin; axonal membrane protein GAP-43; calmodulin-binding protein P-57; growth-associated protein 43; nerve growth-related peptide GAP43; neural phosphoprotein B-50; neuron growth-associated protein 43; protein F1

NCBI Summary for GAP43

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for GAP43

GAP43: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface

Chromosomal Location of Human Ortholog: 3q13.31

Cellular Component: filopodium membrane; axon; cytoplasm; postsynaptic density; plasma membrane; cell junction

Molecular Function: calmodulin binding; protein binding

Biological Process: cell fate commitment; glial cell differentiation; tissue regeneration; regulation of growth; protein kinase C activation; axon choice point recognition; response to wounding; regulation of filopodium formation

Research Articles on GAP43

1. increased expression of TH and GAP43 might be a molecular mechanism for left atrial myoelectricity remodeling of aging atrial fibrillation patients, which might be potential therapeutic targets of atrial fibrillation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GAP43 antibody

Reference Product	PubMed Publications
SYP antibody	>10 publications with GAP43 and SYP
CNTF antibody	>8 publications with GAP43 and CNTF
ELAVL4 antibody	>1 publications with GAP43 and ELAVL4

Pathways associated with anti-GAP43 antibody

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Glial Cell Differentiation Pathway antibodies	Glial Cell Differentiation Pathway Diagram
N-cadherin Signaling Events Pathway antibodies	N-cadherin Signaling Events Pathway Diagram
Spinal Cord Injury Pathway antibodies	Spinal Cord Injury Pathway Diagram

Diseases associated with anti-GAP43 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>135 publications with GAP43 and Nervous System Diseases
Disease Models, Animal Antibodies	>66 publications with GAP43 and Disease Models, Animal
Brain Diseases Antibodies	>59 publications with GAP43 and Brain Diseases
Cardiovascular Diseases Antibodies	>47 publications with GAP43 and Cardiovascular Diseases
Heart Diseases Antibodies	>32 publications with GAP43 and Heart Diseases
Inflammation Antibodies	>24 publications with GAP43 and Inflammation
Nerve Degeneration Antibodies	>23 publications with GAP43 and Nerve Degeneration
Pain Antibodies	>23 publications with GAP43 and Pain
Brain Injuries Antibodies	>23 publications with GAP43 and Brain Injuries
Myocardial Infarction Antibodies	>19 publications with GAP43 and Myocardial Infarction

Organs/Tissues associated with anti-GAP43 antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>270 publications with GAP43 and Nerve
Brain Antibodies	>224 publications with GAP43 and Brain
Eye Antibodies	>31 publications with GAP43 and Eye
Embryonic Tissue Antibodies	>29 publications with GAP43 and Embryonic Tissue
Vascular Antibodies	>17 publications with GAP43 and Vascular
Bone Antibodies	>17 publications with GAP43 and Bone
Connective Tissue Antibodies	>3 publications with GAP43 and Connective Tissue
Lung Antibodies	>2 publications with GAP43 and Lung