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CD268 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS221836

MBS221836 is specific for human CD268, also known as B cell activating factor receptor (BAFF-R). CD268 is a member of the tumour necrosis factor receptor family, which is expressed by B cells.CD268 plays a role in BAFF induced B cell development and survival,… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
CD268, Polyclonal Antibody
Full Product Name
RABBIT ANTI HUMAN CD268
Product Gene Name
anti-CD268 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Specificity
This item is specific for human CD268, also known as B cell activating factor receptor (BAFF-R).

CD268 is a member of the tumour necrosis factor receptor family, which is expressed by B cells.
CD268 plays a role in BAFF induced B cell development and survival, and is thought to be involved in B cell autoimmune diseases.
This item detects a band approximately 20kDa in Western blots of human, mouse and rat spleen lysates.
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
18,935 Da
OMIM
606269
3D Structure
ModBase 3D Structure for Q96RJ3
Perservative Stabilisers
0.02% Sodium Azide
Immunogen
Synthetic peptide corresponding to a region within the C-terminus of human CD268.
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to human CD268 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-CD268 antibody
Immunohistology Paraffin*, Western Blot (WB)
Application Notes for anti-CD268 antibody
Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Western Blotting: Minimum Dilution: 2ug/ml; Maximum Dilution: 5ug/ml

Testing Data #1 of anti-CD268 antibody

Western blot analysis of human (H), mouse (M) and rat (R) spleen lysates probed with Rabbit anti Human CD286 (MBS221836)
Rabbit Anti-CD268 Polyclonal Antibody – Cat# MBS221836

Testing Data #2 of anti-CD268 antibody

Immunohistochemical staining of human tonsil with Rabbit anti CD286 (MBS221836)
Rabbit Anti-CD268 Polyclonal Antibody, Testing Data #2 – Cat# MBS221836

Other Notes

Small volumes of anti-CD268 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD268 purchase

MBS221836 is an antibody targeting CD268. Also known as RABBIT ANTI HUMAN CD268. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD268. It may not necessarily be applicable to this product.

NCBI GI #
16445027
NCBI GeneID
115650
NCBI Accession #
NP_443177.1
UniProt Primary Accession #
Q96RJ3
UniProt Related Accession #
Q96RJ3
GenBank Nucleotide #
NM_052945.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 13C
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 13C
NCBI Official Symbol
TNFRSF13C
NCBI Official Synonym Symbols
BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 13C
UniProt Synonym Protein Names
B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD_antigen: CD268
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF13C
UniProt Synonym Gene Names
BAFFR; BR3; BAFF-R
UniProt Entry Name
TR13C_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 13C; B cell-activating factor receptor; B-cell-activating factor receptor; BAFF receptor; BLyS receptor 3

NCBI Summary for CD268

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD268

BAFF-R: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 22q13.1-q13.31

Cellular Component: integral to membrane; external side of plasma membrane

Biological Process: B cell costimulation; B cell homeostasis; T cell costimulation; positive regulation of B cell proliferation; positive regulation of germinal center formation; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 4
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Research Articles on CD268

1. In view of the restricted expression of the BAFF-R on normal cells and the multiple anti-pre-B ALL activities stimulated by this antibody, a further examination of its use for treatment of pre-B ALL is warranted.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD268 antibody

 Reference Product  PubMed Publications
 TNFSF13B antibody  >121 publications with CD268 and TNFSF13B
 TNFRSF13B antibody  >55 publications with CD268 and TNFRSF13B
 TRAF3 antibody  >8 publications with CD268 and TRAF3
 PTPRC antibody  >1 publications with CD268 and PTPRC
 CXCR5 antibody  >1 publications with CD268 and CXCR5
 POU2AF1 antibody  >1 publications with CD268 and POU2AF1
 TRAF1 antibody  >1 publications with CD268 and TRAF1

Pathways associated with anti-CD268 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram

Diseases associated with anti-CD268 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >141 publications with CD268 and Necrosis
 Immune System Diseases Antibodies  >103 publications with CD268 and Immune System Diseases
 Inflammation Antibodies  >22 publications with CD268 and Inflammation
 Common Variable Immunodeficiency Antibodies  >11 publications with CD268 and Common Variable Immunodeficiency
 Kidney Diseases Antibodies  >7 publications with CD268 and Kidney Diseases
 Hyperplasia Antibodies  >6 publications with CD268 and Hyperplasia
 Atherosclerosis Antibodies  >4 publications with CD268 and Atherosclerosis
 Skin Diseases Antibodies  >4 publications with CD268 and Skin Diseases
 Demyelinating Diseases Antibodies  >4 publications with CD268 and Demyelinating Diseases
 Neoplasms, Experimental Antibodies  >3 publications with CD268 and Neoplasms, Experimental

Organs/Tissues associated with anti-CD268 antibody

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >14 publications with CD268 and Lymph Node
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