GluR2 Antibody – Rabbit Polyclonal

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene. [provided by RefSeq, Jul 2008]

GluR2: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Channel, calcium

Cellular Component: dendrite cytoplasm; cell surface; integral to plasma membrane; dendrite; integral to membrane; terminal button; postsynaptic membrane; synaptic vesicle; cell soma; membrane; synapse; dendritic shaft; endoplasmic reticulum membrane; neuron projection; protein complex; synaptic vesicle membrane; endoplasmic reticulum; postsynaptic density; dendritic spine; perikaryon; presynaptic membrane; asymmetric synapse; growth cone; ionotropic glutamate receptor complex; cell junction

Molecular Function: identical protein binding; protein binding; kainate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; calcium channel regulator activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; receptor activity; protein kinase binding; PDZ domain binding

Biological Process: synaptic transmission; establishment of protein localization; regulation of synaptic transmission, glutamatergic; ionotropic glutamate receptor signaling pathway; response to lithium ion; receptor internalization; regulation of receptor recycling; positive regulation of synaptic transmission; protein tetramerization