GLUCOSE Transporter 2 (SLC2A2) Antibody – Rabbit Polyclonal

GLUT2: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Present at high levels in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion, a glucose metabolism-dependent signaling mechanism. May mediate the bidirectional transfer of glucose across the plasma membrane of hepatocytes. May also participate with the Na( +2)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Required for glucose sensitivity in the hypothalamus and brain stem. Involved in the control of food intake and stimulation of glucose uptake by peripheral tissues.

Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral

Cellular Component: basolateral plasma membrane; brush border membrane; cytoplasm; integral to membrane; plasma membrane; cytosol; endosome; brush border

Molecular Function: D-glucose transmembrane transporter activity; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; insulin receptor binding

Biological Process: response to peptide hormone stimulus; carbohydrate utilization; fructose transport; response to glucose stimulus; glucose transport; transmembrane transport