Mannosidase II (MAN2A1) Antibody – Rabbit Polyclonal

This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]

MAN2A1: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Belongs to the glycosyl hydrolase 38 family.

Protein type: Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; EC 3.2.1.114; Hydrolase

Chromosomal Location of Human Ortholog: 5q21.3

Cellular Component: Golgi membrane; cis-Golgi network; membrane; integral to membrane

Molecular Function: hydrolase activity, hydrolyzing N-glycosyl compounds; zinc ion binding; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; carbohydrate binding

Biological Process: mannose metabolic process; mitochondrion organization and biogenesis; positive regulation of neurogenesis; cellular protein metabolic process; in utero embryonic development; protein amino acid N-linked glycosylation via asparagine; respiratory gaseous exchange; N-glycan processing; liver development; post-translational protein modification; alveolus development; retina morphogenesis in camera-type eye; vacuole organization and biogenesis