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DRP-3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS222504

MBS222504 recognises DRP-3 (also known as TUC-4, CRMP-4 or Ulip-1), a signalling protein showing high expression in neurons during axonal growth. This antibody does not recognises TUC-1, TUC-2, or TUC-3 proteins. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DRP-3, Polyclonal Antibody
Full Product Name
RABBIT ANTI HUMAN DRP-3
Product Gene Name
anti-DRP-3 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Cat, Monkey, Mouse, Rat
Form/Format
Serum
Serum - liquid
Specificity
This item recognises DRP-3 (also known as TUC-4, CRMP-4 or Ulip-1), a signalling protein showing high expression in neurons during axonal growth. This antibody does not recognises TUC-1, TUC-2, or TUC-3 proteins.
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
73,911 Da
OMIM
601168
3D Structure
ModBase 3D Structure for Q14195
Perservative Stabilisers
0.2% Sodium Azide (NaN3)
Immunogen
Peptide with the sequence YDGPVFDLTTTPK.
Target Species
Human
Applications Tested/Suitable for anti-DRP-3 antibody
Immunohistology Frozen, Immunoprecipitation (IP), Western Blot (WB)

Other Notes

Small volumes of anti-DRP-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DRP-3 purchase

MBS222504 is an antibody targeting DRP-3. Also known as RABBIT ANTI HUMAN DRP-3. Reactive in Cat, Monkey, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DRP-3. It may not necessarily be applicable to this product.

NCBI GI #
308818200
NCBI GeneID
1809
NCBI Accession #
NP_001184223.1
UniProt Primary Accession #
Q14195
UniProt Secondary Accession #
Q93012; B3SXQ8
UniProt Related Accession #
Q14195
GenBank Nucleotide #
NM_001197294.1
NCBI Official Full Name
dihydropyrimidinase-related protein 3 isoform 1
NCBI Official Synonym Full Names
dihydropyrimidinase-like 3
NCBI Official Symbol
DPYSL3
NCBI Official Synonym Symbols
DRP3; ULIP; CRMP4; DRP-3; LCRMP; CRMP-4; ULIP-1
UniProt Protein Name
Dihydropyrimidinase-related protein 3
UniProt Synonym Protein Names
Collapsin response mediator protein 4; CRMP-4; Unc-33-like phosphoprotein 1; ULIP-1
Protein Family
Dihydropyrimidinase-related protein
UniProt Gene Name
DPYSL3
UniProt Synonym Gene Names
CRMP4; DRP3; ULIP; ULIP1; DRP-3; CRMP-4; ULIP-1
UniProt Entry Name
DPYL3_HUMAN
NCBI Protein Information
dihydropyrimidinase-related protein 3; collapsin response mediator protein 4 long; unc-33-like phosphoprotein 1

UniProt Comments for DRP-3

CRMP-4: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: filamentous actin; extracellular space; growth cone; lamellipodium; cytosol

Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; phosphoprotein binding; SH3 domain binding

Biological Process: actin crosslink formation; positive regulation of filopodium formation; axon guidance; actin filament bundle formation; response to axon injury; negative regulation of cell migration; protein homooligomerization; pyrimidine base catabolic process
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Research Articles on DRP-3

1. structures provide further insight into the effects of medically relevant mutations of the DPYSL-3 gene encoding CRMP-4 and the putative enzymatic activities of CRMPs

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DRP-3 antibody

 Reference Product  PubMed Publications
 CRMP1 antibody  >7 publications with DRP-3 and CRMP1
 DPYSL2 antibody  >4 publications with DRP-3 and DPYSL2
 CDK5 antibody  >3 publications with DRP-3 and CDK5
 SEMA3A antibody  >3 publications with DRP-3 and SEMA3A
 DPYSL4 antibody  >2 publications with DRP-3 and DPYSL4
 PLXNA1 antibody  >1 publications with DRP-3 and PLXNA1
 PLXNA3 antibody  >1 publications with DRP-3 and PLXNA3
 PLXNA4 antibody  >1 publications with DRP-3 and PLXNA4
 DPYSL5 antibody  >1 publications with DRP-3 and DPYSL5

Pathways associated with anti-DRP-3 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CRMPs In Sema3A Signaling Pathway antibodies  CRMPs In Sema3A Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram

Diseases associated with anti-DRP-3 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >8 publications with DRP-3 and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with DRP-3 and Brain Diseases
 Nerve Degeneration Antibodies  >3 publications with DRP-3 and Nerve Degeneration
 Abnormalities, Multiple Antibodies  >2 publications with DRP-3 and Abnormalities, Multiple
 Neurobehavioral Manifestations Antibodies  >1 publications with DRP-3 and Neurobehavioral Manifestations
 Abnormalities, Drug-Induced Antibodies  >1 publications with DRP-3 and Abnormalities, Drug-Induced
 Liver Diseases Antibodies  >1 publications with DRP-3 and Liver Diseases
 Prenatal Injuries Antibodies  >1 publications with DRP-3 and Prenatal Injuries
 Inflammation Antibodies  >1 publications with DRP-3 and Inflammation
 Liver Neoplasms Antibodies  >1 publications with DRP-3 and Liver Neoplasms

Organs/Tissues associated with anti-DRP-3 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >31 publications with DRP-3 and Muscle
 Nerve Antibodies  >28 publications with DRP-3 and Nerve
 Brain Antibodies  >21 publications with DRP-3 and Brain
 Embryonic Tissue Antibodies  >7 publications with DRP-3 and Embryonic Tissue
 Lung Antibodies  >3 publications with DRP-3 and Lung
 Liver Antibodies  >3 publications with DRP-3 and Liver
 Heart Antibodies  >2 publications with DRP-3 and Heart
 Vascular Antibodies  >2 publications with DRP-3 and Vascular
 Kidney Antibodies  >2 publications with DRP-3 and Kidney
 Thyroid Antibodies  >2 publications with DRP-3 and Thyroid
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