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iASPP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS222822

Rabbit anti Human iASPP antibody detects human inhibitor of apoptosis stimulating protein of p53 (iASPP), which plays a central role in regulation of apoptosis and transcription via its interaction with NFkB and p53 proteins. At present, the iASPP gene is… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
iASPP, Polyclonal Antibody
Full Product Name
RABBIT ANTI HUMAN iASPP
Product Gene Name
anti-iASPP antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Dog (Expected from Sequence), Mouse (Expected from Sequence)
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
89,091 Da
OMIM
607463
3D Structure
ModBase 3D Structure for Q8WUF5
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Buffer Solution
Phosphate buffered saline
Antiserum Preparation
Antisera to human iASPP were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-iASPP antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-iASPP antibody
Western Blot: This item detects a bands of approximately 100 and 50kDa corresponding to iASPP isoforms 1 and 2 respectively.
ELISA: Minimum Dilution: 1/40000; Maximum Dilution: 1/160000
Western Blotting: Minimum Dilution: 1/1000; Maximum Dilution: 1/5000

Other Notes

Small volumes of anti-iASPP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for iASPP purchase

MBS222822 is an antibody targeting iASPP. Also known as RABBIT ANTI HUMAN iASPP. Reactive in Dog (Expected from Sequence), Mouse (Expected from Sequence). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for iASPP. It may not necessarily be applicable to this product.

NCBI GI #
215820635
NCBI GeneID
10848
NCBI Accession #
NP_001135974.1
UniProt Primary Accession #
Q8WUF5
UniProt Secondary Accession #
Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q9Y290
UniProt Related Accession #
Q8WUF5
GenBank Nucleotide #
NM_001142502.1
NCBI Official Full Name
relA-associated inhibitor
NCBI Official Synonym Full Names
protein phosphatase 1, regulatory subunit 13 like
NCBI Official Symbol
PPP1R13L
NCBI Official Synonym Symbols
RAI; RAI4; IASPP; NKIP1
UniProt Protein Name
RelA-associated inhibitor
UniProt Synonym Protein Names
Inhibitor of ASPP protein; Protein iASPP; NFkB-interacting protein 1; PPP1R13B-like protein
Protein Family
Apoptotic enhancer 1 protein
UniProt Gene Name
PPP1R13L
UniProt Synonym Gene Names
IASPP; NKIP1; PPP1R13BL; RAI; Protein iASPP
UniProt Entry Name
IASPP_HUMAN
NCBI Protein Information
relA-associated inhibitor; NFkB interacting protein 1; NFkB-interacting protein 1; PPP1R13B-like protein; inhibitor of ASPP protein; inhibitor of apoptosis stimulating protein of p53; protein iASPP; protein phosphatase 1, regulatory (inhibitor) subunit 13 like; retinoic acid induced 4

NCBI Summary for iASPP

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

UniProt Comments for iASPP

PPP1R13L: an oncoprotein that interacts with and inhibits NF-kappaB, Sp1 and p53. Plays a central role in regulation of apoptosis and transcription. May inhibit p53 by preventing its association with ASPP1 or ASPP2, thereby suppressing the subsequent activation of apoptosis. Required for neuronal survival after axonal injury. Two alternatively spliced isoforms have been described. Isoform 1 is preferrentially found in the cytoplasm; isoform 2 is nuclear.

Protein type: Apoptosis; Phosphatase, regulatory subunit; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: intercellular bridge; cytoplasm; nucleus; cell junction

Molecular Function: identical protein binding; protein binding; transcription factor binding; transcription corepressor activity

Biological Process: transcription, DNA-dependent; apoptosis; multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; multicellular organismal homeostasis; embryonic camera-type eye development; post-embryonic development; cardiac muscle contraction; hair cycle
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Research Articles on iASPP

1. Hematopoietic cells can be protected against apoptosis by iASPP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-iASPP antibody

 Reference Product  PubMed Publications
 CD3EAP antibody  >15 publications with iASPP and CD3EAP
 TP53 antibody  >10 publications with iASPP and TP53
 TP63 antibody  >3 publications with iASPP and TP63
 SP1 antibody  >2 publications with iASPP and SP1

Pathways associated with anti-iASPP antibody

 Products by Pathway  Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram

Diseases associated with anti-iASPP antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >16 publications with iASPP and Lung Diseases
 Lung Neoplasms Antibodies  >15 publications with iASPP and Lung Neoplasms
 Breast Neoplasms Antibodies  >10 publications with iASPP and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >6 publications with iASPP and Neoplasm Metastasis
 Leukemia Antibodies  >6 publications with iASPP and Leukemia
 Nervous System Diseases Antibodies  >5 publications with iASPP and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >5 publications with iASPP and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >4 publications with iASPP and Liver Diseases
 Disease Models, Animal Antibodies  >3 publications with iASPP and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >3 publications with iASPP and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-iASPP antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >17 publications with iASPP and Lung
 Skin Antibodies  >7 publications with iASPP and Skin
 Liver Antibodies  >4 publications with iASPP and Liver
 Placenta Antibodies  >3 publications with iASPP and Placenta
 Prostate Antibodies  >3 publications with iASPP and Prostate
 Heart Antibodies  >3 publications with iASPP and Heart
 Embryonic Tissue Antibodies  >3 publications with iASPP and Embryonic Tissue
 Brain Antibodies  >2 publications with iASPP and Brain
 Stomach Antibodies  >2 publications with iASPP and Stomach
 Bone Antibodies  >2 publications with iASPP and Bone
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