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STEAP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS222893

MBS222893 recognises STEAP1 (six transmembrane epithelial antigen of the prostate), a 39kD protein which is a member of a family of cell surface serpentine transmembrane antigens of the prostate. STEAP1 is predominantly expressed in human prostate and is… More details

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Testing Data View PDF
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Product Overview

Product Name
STEAP1, Polyclonal Antibody
Full Product Name
RABBIT ANTI STEAP1 (C-TERMINAL)
Product Gene Name
anti-STEAP1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Specificity
This item recognises STEAP1 (six transmembrane epithelial antigen of the prostate), a 39kD protein which is a member of a family of cell surface serpentine transmembrane antigens of the prostate.

STEAP1 is predominantly expressed in human prostate and is up-regulated in several cancer lines including prostate, ovarian, cervical, breast, testicular, bladder, colon and Ewing sarcoma. It is significantly expressed at cell-cell junctions and has been shown to be a target of human CD8 T cells. This indicates that it could be used as a potential target for cancer immunotherapy. This antibody does not cross-react with other STEAP-proteins.
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
39,851 Da
OMIM
604415
3D Structure
ModBase 3D Structure for Q9UHE8
Perservative Stabilisers
0.02% Sodium Azide
Preparation||Antisera to human STEAP (CT) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen
An 18 amino acid peptide located near the c-terminal region of human STEAP1.
Buffer Solution||Phosphate buffered saline
Target Species
Human
Applications Tested/Suitable for anti-STEAP1 antibody
Immunohistology Paraffin*, Western Blot (WB)
Application Notes for anti-STEAP1 antibody
Western Blot: This item detects a band of approximately 40kDa in human spleen cell lysates.
Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 1; Maximum Dilution: 2ug/ml

Testing Data #1 of anti-STEAP1 antibody

Western blot analysis of human spleen lysate probed with Rabbit ati Human STEAP1 (MBS222893) at 1(A) and 2(B) ug/ml
Rabbit Anti-STEAP1 Polyclonal Antibody – Cat# MBS222893

Testing Data #2 of anti-STEAP1 antibody

Formalin fixed, paraffin embedded human spleen stained with Rabbit anti Human STEAP1 (MBS222893) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Rabbit Anti-STEAP1 Polyclonal Antibody, Testing Data #2 – Cat# MBS222893

Other Notes

Small volumes of anti-STEAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STEAP1 purchase

MBS222893 is an antibody targeting STEAP1. Also known as RABBIT ANTI STEAP1 (C-TERMINAL). Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STEAP1. It may not necessarily be applicable to this product.

NCBI GI #
9558759
NCBI GeneID
26872
NCBI Accession #
NP_036581.1
UniProt Primary Accession #
Q9UHE8
UniProt Secondary Accession #
O95034; A4D1E0
UniProt Related Accession #
Q9UHE8
GenBank Nucleotide #
NM_012449.2
NCBI Official Full Name
metalloreductase STEAP1
NCBI Official Synonym Full Names
six transmembrane epithelial antigen of the prostate 1
NCBI Official Symbol
STEAP1
NCBI Official Synonym Symbols
STEAP; PRSS24
UniProt Protein Name
Metalloreductase STEAP1
UniProt Synonym Protein Names
Six-transmembrane epithelial antigen of prostate 1
Protein Family
Metalloreductase
UniProt Gene Name
STEAP1
UniProt Synonym Gene Names
PRSS24; STEAP
UniProt Entry Name
STEA1_HUMAN
NCBI Protein Information
metalloreductase STEAP1; six-transmembrane epithelial antigen of prostate 1

NCBI Summary for STEAP1

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]
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UniProt Comments for STEAP1

STEAP1: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family.

Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase; EC 1.16.1.-

Chromosomal Location of Human Ortholog: 7q21

Cellular Component: membrane; integral to plasma membrane; plasma membrane; endosome membrane; intercellular junction

Molecular Function: transporter activity; channel activity; metal ion binding; oxidoreductase activity

Biological Process: iron ion homeostasis; ion transport; transmembrane transport
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Research Articles on STEAP1

1. These findings highlight the ability of immuno-PET with (89)Zr-2109A to detect acute changes in STEAP1 expression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STEAP1 antibody

 Reference Product  PubMed Publications
 STEAP2 antibody  >8 publications with STEAP1 and STEAP2
 PSCA antibody  >2 publications with STEAP1 and PSCA

Pathways associated with anti-STEAP1 antibody

 Products by Pathway  Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram

Diseases associated with anti-STEAP1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >6 publications with STEAP1 and Adenocarcinoma
 Hyperplasia Antibodies  >4 publications with STEAP1 and Hyperplasia
 Breast Neoplasms Antibodies  >4 publications with STEAP1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >4 publications with STEAP1 and Lung Neoplasms
 Lung Diseases Antibodies  >3 publications with STEAP1 and Lung Diseases
 Neoplasms, Experimental Antibodies  >3 publications with STEAP1 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >3 publications with STEAP1 and Ovarian Neoplasms
 Hypertrophy Antibodies  >1 publications with STEAP1 and Hypertrophy
 Disease Models, Animal Antibodies  >1 publications with STEAP1 and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with STEAP1 and Kidney Diseases

Organs/Tissues associated with anti-STEAP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >38 publications with STEAP1 and Prostate
 Bone Antibodies  >9 publications with STEAP1 and Bone
 Lung Antibodies  >6 publications with STEAP1 and Lung
 Testis Antibodies  >2 publications with STEAP1 and Testis
 Pancreas Antibodies  >2 publications with STEAP1 and Pancreas
 Liver Antibodies  >1 publications with STEAP1 and Liver
 Brain Antibodies  >1 publications with STEAP1 and Brain
 Mammary Gland Antibodies  >1 publications with STEAP1 and Mammary Gland
 Embryonic Tissue Antibodies  >1 publications with STEAP1 and Embryonic Tissue
 Ovary Antibodies  >1 publications with STEAP1 and Ovary
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