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IFN BETA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS223102

MBS223102 recognises interferon beta (IFN-beta), a 22kD member of the type I alpha/beta interferon family. IFN beta, initially described as fibroblast interferon, is produced predominantly by fibroblasts and some epithelial cells. Type 1 interferons are… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IFN BETA, Polyclonal Antibody
Full Product Name
RABBIT ANTI IFN BETA
Product Gene Name
anti-IFN BETA antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Specificity
This item recognises interferon beta (IFN-beta), a 22kD member of the type I alpha/beta interferon family. IFN beta, initially described as fibroblast interferon, is produced predominantly by fibroblasts and some epithelial cells. Type 1 interferons are produced primarily in response to viral infections as part of the host immune response and can also inhibit the development of tumours. IFN-beta is involved in the regulation of non-specific humoural immune responses and responses against viral infections.
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
22,294 Da
OMIM
147640
3D Structure
ModBase 3D Structure for P01574
Perservative Stabilisers
0.02% Sodium Azide
Immunogen
A 17 amino acid peptide located near the centre of human IFN Beta.
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to human IFN Beta were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-IFN BETA antibody
Immunohistology Paraffin*, Western Blot (WB)
Application Notes for anti-IFN BETA antibody
Western Blot: This item detects a band of approximately 15kDa in A20 cell lysates.
Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Maximum Dilution: 5ug/ml

Testing Data #1 of anti-IFN BETA antibody

Western blot analysis of whole cell lysate from A-20 mouse B-cell lymphoma probed with Rabbit anti Human IFN beta (MBS223102)
Rabbit Anti-IFN BETA Polyclonal Antibody – Cat# MBS223102

Testing Data #2 of anti-IFN BETA antibody

Formalin fixed, paraffin embedded human liver stained with Rabbit anti Human IFN beta (MBS223102) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Rabbit Anti-IFN BETA Polyclonal Antibody, Testing Data #2 – Cat# MBS223102

Other Notes

Small volumes of anti-IFN BETA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFN BETA purchase

MBS223102 is an antibody targeting IFN BETA. Also known as RABBIT ANTI IFN BETA. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IFN BETA. It may not necessarily be applicable to this product.

NCBI GI #
4504603
NCBI GeneID
3456
NCBI Accession #
NP_002167.1
UniProt Primary Accession #
P01574
UniProt Secondary Accession #
Q5VWC9
UniProt Related Accession #
P01574
GenBank Nucleotide #
NM_002176.2
NCBI Official Full Name
interferon beta
NCBI Official Synonym Full Names
interferon, beta 1, fibroblast
NCBI Official Symbol
IFNB1
NCBI Official Synonym Symbols
IFB; IFF; IFNB
UniProt Protein Name
Interferon beta
UniProt Synonym Protein Names
Fibroblast interferon
Protein Family
Interferon
UniProt Gene Name
IFNB1
UniProt Synonym Gene Names
IFB; IFNB; IFN-beta
UniProt Entry Name
IFNB_HUMAN
NCBI Protein Information
interferon beta; IFN-beta; fibroblast interferon

UniProt Comments for IFN BETA

IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: extracellular space; extracellular region

Molecular Function: interferon-alpha/beta receptor binding; cytokine activity

Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; response to virus; regulation of MHC class I biosynthetic process; natural killer cell activation; negative regulation of T cell differentiation; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; cell surface receptor linked signal transduction; negative regulation of viral genome replication; B cell differentiation; positive regulation of innate immune response; defense response to bacterium; natural killer cell activation during immune response; innate immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; defense response to virus; positive regulation of peptidyl-serine phosphorylation of STAT protein; B cell activation during immune response
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Research Articles on IFN BETA

1. A20 has a novel atheroprotective function in vascular cells through modulation of IFNgamma/STAT1 signaling in an IFNbeta-dependent, but NF-kappaB-independent, manner

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IFN BETA antibody

 Reference Product  PubMed Publications
 IRF3 antibody  >18 publications with IFN BETA and IRF3
 IFNAR1 antibody  >6 publications with IFN BETA and IFNAR1
 IRF7 antibody  >4 publications with IFN BETA and IRF7
 STAT2 antibody  >3 publications with IFN BETA and STAT2
 EP300 antibody  >1 publications with IFN BETA and EP300
 CREBBP antibody  >1 publications with IFN BETA and CREBBP
 IRF1 antibody  >1 publications with IFN BETA and IRF1
 IFNAR2 antibody  >1 publications with IFN BETA and IFNAR2

Pathways associated with anti-IFN BETA antibody

 Products by Pathway  Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram

Diseases associated with anti-IFN BETA antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >9 publications with IFN BETA and Immune System Diseases
 Inflammation Antibodies  >8 publications with IFN BETA and Inflammation
 Necrosis Antibodies  >7 publications with IFN BETA and Necrosis
 Carcinoma Antibodies  >4 publications with IFN BETA and Carcinoma
 Melanoma Antibodies  >3 publications with IFN BETA and Melanoma
 Leukemia Antibodies  >3 publications with IFN BETA and Leukemia
 Lung Neoplasms Antibodies  >3 publications with IFN BETA and Lung Neoplasms
 Heart Diseases Antibodies  >2 publications with IFN BETA and Heart Diseases
 Multiple Sclerosis Antibodies  >2 publications with IFN BETA and Multiple Sclerosis
 Pancreatic Neoplasms Antibodies  >2 publications with IFN BETA and Pancreatic Neoplasms
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