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Calcitonin RECEPTOR (CALCR) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS223231

Rabbit anti Rat Calcitonin Receptor antibody recognizes the calcitonin receptor in human, mouse and rat. The calcitonin receptor is a seven transmembrane domain cell surface protein which is coupled to G protein messenger systems. MBS221657 recognizes an… More details

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Product Overview

Product Name
CALCITONIN RECEPTOR (Calcr), Polyclonal Antibody
Full Product Name
RABBIT ANTI RAT CALCITONIN RECEPTOR
Product Gene Name
anti-Calcr antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
Molecular Weight
55,879 Da
3D Structure
ModBase 3D Structure for P32214
Perservative Stabilisers
0.09% Sodium Azide
Immunogen
Synthetic peptide derived from a C-terminal sequence of rat calcitonin receptor.
Histology Positive Control Tissue||Kidney, cultured osteoclasts.
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to calcitonin receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography on Protein A.
Target Species
Rat
Applications Tested/Suitable for anti-Calcr antibody
Immunohistology Frozen, ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin*
Application Notes for anti-Calcr antibody
Immunohistology - Frozen: Minimum Dilution: 1/10; Maximum Dilution: 1/50;
Immunohistology - Paraffin: Minimum Dilution: 1/10; Maximum Dilution: 1/50; Application Note: The use of 4% paraformaldehyde fixation, rather than formalin fixation is recommended.

A sensitive detection system is also recommended. e.g. A catalysed signal amplification system.

Other Notes

Small volumes of anti-Calcr antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Calcr purchase

MBS223231 is an antibody targeting Calcr. Also known as RABBIT ANTI RAT CALCITONIN RECEPTOR. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Calcr. It may not necessarily be applicable to this product.

NCBI GI #
77404382
NCBI GeneID
116506
NCBI Accession #
NP_001029187.1
UniProt Primary Accession #
P32214
UniProt Secondary Accession #
P32213
UniProt Related Accession #
P32214
GenBank Nucleotide #
NM_001034015.1
NCBI Official Full Name
calcitonin receptor isoform 1a
NCBI Official Synonym Full Names
calcitonin receptor
NCBI Official Symbol
Calcr
UniProt Protein Name
Calcitonin receptor
UniProt Synonym Protein Names
C1A/C1B
Protein Family
Calcitonin receptor
UniProt Gene Name
Calcr
UniProt Synonym Gene Names
CT-R
UniProt Entry Name
CALCR_RAT
NCBI Protein Information
calcitonin receptor; C1A/C1B; CT-R

NCBI Summary for Calcr

receptor for calcitonin; acts via adenylate cyclase signaling [RGD, Feb 2006]

UniProt Comments for Calcr

CALCR: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Receptor, GPCR

Cellular Component: neuron projection; cell soma; axon; plasma membrane; integral to membrane; acrosome; cytosol; cilium

Molecular Function: calcitonin binding; receptor activity; protein transporter activity; calcitonin receptor activity

Biological Process: regulation of bone resorption; response to glucocorticoid stimulus; adenylate cyclase activation; osteoclast differentiation; regulation of mRNA stability; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; protein transport; elevation of cytosolic calcium ion concentration; phospholipase C activation; receptor internalization; positive regulation of cAMP biosynthetic process; negative regulation of ossification; positive regulation of adenylate cyclase activity
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Research Articles on Calcr

1. In conclusion, oral KBP-042 is a novel DACRA, which exerts antiobesity and antidiabetic efficacy by dual modulation of insulin sensitivity and directly decelerating stress on the pancreatic alpha- and beta-cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Calcr antibody

 Products by Pathway  Pathway Diagram
 Calcitonin-like Ligand Receptors Pathway antibodies  Calcitonin-like Ligand Receptors Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-Calcr antibody

 Disease Name  Pubmed Publications
 Osteoporosis Antibodies  >10 publications with Calcr and Osteoporosis
 Lung Diseases Antibodies  >4 publications with Calcr and Lung Diseases
 Inflammation Antibodies  >3 publications with Calcr and Inflammation
 Fibrosis Antibodies  >3 publications with Calcr and Fibrosis
 Necrosis Antibodies  >2 publications with Calcr and Necrosis
 Death Antibodies  >2 publications with Calcr and Death
 Nervous System Diseases Antibodies  >1 publications with Calcr and Nervous System Diseases
 Insulin Resistance Antibodies  >1 publications with Calcr and Insulin Resistance
 Kidney Diseases Antibodies  >1 publications with Calcr and Kidney Diseases
 Memory Disorders Antibodies  >1 publications with Calcr and Memory Disorders

Organs/Tissues associated with anti-Calcr antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with Calcr and Brain
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