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DcR3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS223341

Rabbit anti Human DcR3 (N-Terminal) antibody recognizes the amino Terminal of human DcR3, otherwise known as Decoy Receptor 3, a 33kDa member of the tumour necrosis factor receptor superfamily. DcR3 acts as a receptor for FasL and LIGHT, preventing them from… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DcR3, Polyclonal Antibody
Full Product Name
RABBIT ANTI HUMAN DcR3 (N-TERMINAL)
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 0.5 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
32,680 Da
OMIM
603361
3D Structure
ModBase 3D Structure for O95407
Perservative Stabilisers
0.02% Sodium Azide (NaN3)
Immunogen
A peptide corresponding to amino acids near the amino-terminus of human DcR3 precursor.
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antiserum to human DcR3 (NT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.
Target Species
Human
Applications Tested/Suitable for anti-DcR3 antibody
Immunohistology Paraffin*, Western Blot (WB)
Application Notes for anti-DcR3 antibody
Western Blot: This item detects a band of approximately 33kDa in human heart lysate.
Immunohistology - Paraffin: Maximum Dilution: 1ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 1.0ug/ml

Testing Data #1 of anti-DcR3 antibody

Western blot analysis of human lysates from heart (H), brain (B) and kidney (K) probed with Rabbit anti Human DcR3 (MBS223341)
Rabbit Anti-DcR3 Polyclonal Antibody – Cat# MBS223341

Testing Data #2 of anti-DcR3 antibody

Immunohistochemical staining of human heart with Rabbit anti Human DcR3 (MBS223341)
Rabbit Anti-DcR3 Polyclonal Antibody, Testing Data #2 – Cat# MBS223341

Other Notes

Small volumes of anti-DcR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DcR3 purchase

MBS223341 is an antibody targeting DcR3. Also known as RABBIT ANTI HUMAN DcR3 (N-TERMINAL). Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DcR3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 6B
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 6b, decoy
NCBI Official Symbol
TNFRSF6B
NCBI Official Synonym Symbols
M68; TR6; DCR3; M68E; DJ583P15.1.1
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 6B
UniProt Synonym Protein Names
Decoy receptor 3; DcR3; Decoy receptor for Fas ligand; M68
UniProt Gene Name
TNFRSF6B
UniProt Synonym Gene Names
DCR3; TR6; DcR3
UniProt Entry Name
TNF6B_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 6B; decoy receptor 3; decoy receptor for Fas ligand

NCBI Summary for DcR3

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
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UniProt Comments for DcR3

TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: extracellular space

Molecular Function: protein binding; receptor activity

Biological Process: apoptosis; negative regulation of apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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