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Il-22 RECEPTOR (IL22RA1) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS223582

Goat anti Human Interleukin-22 Receptor (N-Terminal) antibody specifically recognizes an epitope within the N-terminal (NT) region of human interleukin-22 receptor (IL-22R), also known as IL-22R alpha-1 (IL22RA1), a member of the type II cytokine receptor… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IL-22 RECEPTOR (IL22RA1), Polyclonal Antibody
Full Product Name
GOAT ANTI HUMAN INTERLEUKIN-22 RECEPTOR (N-TERMINAL)
Product Gene Name
anti-IL22RA1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
63,077 Da
OMIM
605457
3D Structure
ModBase 3D Structure for Q8N6P7
Perservative Stabilisers
0.1% Sodium Azide (NaN3)
Histology Positive Control Tissue
Spleen or tonsil
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antiserum to human IL-22R (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-IL22RA1 antibody
ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin
Application Notes for anti-IL22RA1 antibody
ELISA: Minimum Dilution: 1/50000;
Immunofluorescence: Minimum Dilution: 1/100;
Immunohistology - Paraffin: Minimum Dilution: 1/150

Testing Data #1 of anti-IL22RA1 antibody

Staining of paraffin embedded human spleen with Goat anti human IL-22 Receptor (MBS223582)
Goat Anti-IL22RA1 Polyclonal Antibody – Cat# MBS223582

Testing Data #2 of anti-IL22RA1 antibody

Staining of paraffin embedded human tonsil with Goat anti human IL-22 Receptor (MBS223582)
Goat Anti-IL22RA1 Polyclonal Antibody, Testing Data #2 – Cat# MBS223582

Other Notes

Small volumes of anti-IL22RA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL22RA1 purchase

MBS223582 is an antibody targeting IL22RA1. Also known as GOAT ANTI HUMAN INTERLEUKIN-22 RECEPTOR (N-TERMINAL). Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for IL22RA1. It may not necessarily be applicable to this product.

NCBI GI #
31317239
NCBI GeneID
58985
NCBI Accession #
NP_067081.2
UniProt Primary Accession #
Q8N6P7
UniProt Secondary Accession #
Q9HB22; A8K839; B2R9Y9
UniProt Related Accession #
Q8N6P7
GenBank Nucleotide #
NM_021258.3
NCBI Official Full Name
interleukin-22 receptor subunit alpha-1
NCBI Official Synonym Full Names
interleukin 22 receptor, alpha 1
NCBI Official Symbol
IL22RA1
NCBI Official Synonym Symbols
IL22R; CRF2-9; IL22R1
UniProt Protein Name
Interleukin-22 receptor subunit alpha-1
UniProt Synonym Protein Names
Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; CRF2-9; ZcytoR11
Protein Family
Interleukin-22 receptor
UniProt Gene Name
IL22RA1
UniProt Synonym Gene Names
IL22R; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; CRF2-9
UniProt Entry Name
I22R1_HUMAN
NCBI Protein Information
interleukin-22 receptor subunit alpha-1; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9; zcytoR11

NCBI Summary for IL22RA1

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL22RA1

IL22RA1: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: plasma membrane; integral to membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interferon receptor activity; interleukin-20 binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to Gram-negative bacterium
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Research Articles on IL22RA1

1. IL-22 has restricted tissue specificity as its unique receptor IL-22R1 is exclusively expressed on epithelial and tissue cells, but not immune cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL22RA1 antibody

 Reference Product  PubMed Publications
 IL22 antibody  >5 publications with IL22RA1 and IL22
 IL20 antibody  >2 publications with IL22RA1 and IL20
 IL24 antibody  >2 publications with IL22RA1 and IL24
 IL10RB antibody  >2 publications with IL22RA1 and IL10RB

Pathways associated with anti-IL22RA1 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-IL22RA1 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >2 publications with IL22RA1 and Immune System Diseases
 Carcinoma Antibodies  >1 publications with IL22RA1 and Carcinoma
 Neoplasms, Experimental Antibodies  >1 publications with IL22RA1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >1 publications with IL22RA1 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with IL22RA1 and Kidney Diseases
 Inflammation Antibodies  >1 publications with IL22RA1 and Inflammation

Organs/Tissues associated with anti-IL22RA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >3 publications with IL22RA1 and Skin
 Kidney Antibodies  >1 publications with IL22RA1 and Kidney
 Thyroid Antibodies  >1 publications with IL22RA1 and Thyroid
 Bladder Antibodies  >1 publications with IL22RA1 and Bladder
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