Sheep Anti-H2B Polyclonal Antibody – Cat# MBS223591

Histone H2B detected with Sheep anti Bovine Histone H2B (MBS223591)

HISTONE H2B (H2B) Antibody – Sheep Polyclonal

Name: H2B Antibody; Polyclonal; Sheep; MyBioSource
Brand: MyBioSource
SKU: MBS223591
Price: 390 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS223591

This antibody has been found to react with the following: H2B 100% H1 >=25% H2A = H4 >=25% H3 >=25% More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

HISTONE H2B, Polyclonal Antibody

Full Product Name

SHEEP ANTI BOVINE HISTONE H2B

Product Gene Name

anti-H2B antibody

Clonality

Polyclonal

Isotype

IgG

Host

Sheep

Form/Format

Purified
Purified IgG - liquid

Concentration

IgG concentration 5mg/ml (lot specific)

Specificity

This antibody has been found to react with the following: H2B 100% H1 >=25% H2A = H4 >=25% H3 >=25%

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

13,906 Da

3D Structure

ModBase 3D Structure for P62808

Perservative Stabilisers

0.09% Sodium Azide (NaN3)
Preparation||Purified IgG prepared by affinity chromatography

Immunogen

Hostone H2B, slightly lysine-rich subgroup f2b from calf thymus.
Buffer Solution||Phosphate buffered saline

Target Species

Bovine

Applications Tested/Suitable for anti-H2B antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-H2B antibody

ELISA: Minimum Dilution: 1/500; Maximum Dilution: 1/3200;
Western Blotting: Minimum Dilution: 1/100; Maximum Dilution: 1/1000

Other Notes

Small volumes of anti-H2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for H2B purchase

MBS223591 is an antibody targeting H2B. Also known as SHEEP ANTI BOVINE HISTONE H2B. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for H2B. It may not necessarily be applicable to this product.

NCBI GI #

82697375

NCBI GeneID

615043

NCBI Accession #

NP_001032546.1

UniProt Primary Accession #

P62808

UniProt Secondary Accession #

P02278; Q32PE8; A1L599; A5PJG5

UniProt Related Accession #

P62808

GenBank Nucleotide #

NM_001037469.2

NCBI Official Full Name

histone H2B type 1

NCBI Official Synonym Full Names

histone H2B-like

NCBI Official Symbol

H2B

UniProt Protein Name

Histone H2B type 1

Protein Family

Histone H2B subacrosomal

UniProt Entry Name

H2B1_BOVIN

NCBI Protein Information

histone H2B type 1

UniProt Comments for H2B

H2B1C: a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: nucleoplasm; extracellular space; nucleosome; nucleus

Molecular Function: DNA binding; protein heterodimerization activity

Biological Process: nucleosome assembly; defense response to Gram-positive bacterium; establishment and/or maintenance of chromatin architecture; innate immune response in mucosa; antibacterial humoral response

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-H2B antibody

Reference Product	PubMed Publications
H2AFX antibody	>8 publications with H2B and H2AFX

Pathways associated with anti-H2B antibody

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Viral Carcinogenesis Pathway antibodies	Viral Carcinogenesis Pathway Diagram
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Diseases associated with anti-H2B antibody

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>173 publications with H2B and Immune System Diseases
Disease Models, Animal Antibodies	>96 publications with H2B and Disease Models, Animal
Neoplasms, Experimental Antibodies	>78 publications with H2B and Neoplasms, Experimental
Carcinoma Antibodies	>65 publications with H2B and Carcinoma
Liver Diseases Antibodies	>38 publications with H2B and Liver Diseases
Nervous System Diseases Antibodies	>28 publications with H2B and Nervous System Diseases
Cardiovascular Diseases Antibodies	>27 publications with H2B and Cardiovascular Diseases
Necrosis Antibodies	>26 publications with H2B and Necrosis
Kidney Diseases Antibodies	>26 publications with H2B and Kidney Diseases
Liver Neoplasms, Experimental Antibodies	>22 publications with H2B and Liver Neoplasms, Experimental

Organs/Tissues associated with anti-H2B antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>195 publications with H2B and Liver
Testis Antibodies	>98 publications with H2B and Testis
Intestine Antibodies	>18 publications with H2B and Intestine