Rabbit Anti-KRT19 Polyclonal Antibody – Cat# MBS223647

Staining of formalin fixed, paraffin embedded human placenta with Rabbit anti Human Cytokeratin 19 (MBS223647)

Cytokeratin 19 (KRT19) Antibody – Rabbit Polyclonal

Name: KRT19 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS223647
Price: 780 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS223647

Rabbit anti Mouse Cytokeratin 19 antibody recognises the 40kD cytokeratin corresponding to mouse cytokeratin 19. Cytokeratin 19 is expressed by many simple and non-keratinizing normal and neoplastic epithelia, including glandular and ductal epithelia. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CYTOKERATIN 19 (Krt19), Polyclonal Antibody

Full Product Name

RABBIT ANTI MOUSE CYTOKERATIN 19

Product Gene Name

anti-Krt19 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Monkey

Form/Format

Purified
Purified IgG - liquid

Concentration

IgG concentration 1.0mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

44,542 Da

3D Structure

ModBase 3D Structure for P19001

Perservative Stabilisers

0.09% Sodium Azide (NaN3)

Histology Positive Control Tissue

Mouse placenta
Buffer Solution||Phosphate buffered saline

Antiserum Preparation

Antisera to mouse Cytokeratin 19 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.

Target Species

Mouse

Applications Tested/Suitable for anti-Krt19 antibody

ELISA (EIA), Immunohistology Paraffin*

Application Notes for anti-Krt19 antibody

Immunohistology - Paraffin: Maximum Dilution: 5ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

Other Notes

Small volumes of anti-Krt19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Krt19 purchase

MBS223647 is an antibody targeting Krt19. Also known as RABBIT ANTI MOUSE CYTOKERATIN 19. Reactive in Human, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Krt19. It may not necessarily be applicable to this product.

NCBI GI #

6680606

NCBI GeneID

16669

NCBI Accession #

NP_032497.1

UniProt Primary Accession #

P19001

UniProt Related Accession #

P19001

GenBank Nucleotide #

NM_008471.2

NCBI Official Full Name

keratin, type I cytoskeletal 19

NCBI Official Synonym Full Names

keratin 19

NCBI Official Symbol

Krt19

NCBI Official Synonym Symbols

K19; EndoC; Krt1-19; AI663979; Krt-1.19

UniProt Protein Name

Keratin, type I cytoskeletal 19

UniProt Synonym Protein Names

Cytokeratin-19; CK-19; Keratin-19; K19

Protein Family

Keratin

UniProt Gene Name

Krt19

UniProt Synonym Gene Names

Krt1-19; CK-19; K19

UniProt Entry Name

K1C19_MOUSE

NCBI Protein Information

keratin, type I cytoskeletal 19; CK-19; cytokeratin 19; cytokeratin-19; keratin complex 1, acidic, gene 19

UniProt Comments for Krt19

K19: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 differs from all other IF proteins in lacking the C-terminal tail domain. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis.

Protein type: Cytoskeletal

Cellular Component: dystrophin-associated glycoprotein complex; costamere; intermediate filament; Z disc; sarcolemma

Molecular Function: protein binding; structural constituent of muscle; protein complex binding; structural molecule activity

Biological Process: sarcomere organization

Research Articles on Krt19

1. Branched desmin-deficient (DKO) myofibers show significantly faster rates of calcium ion (Ca2+) clearance, with milder branching phenotype observed in DKO muscle suggesting that absence of keratin-19 corrects the defect created by absence of desmin alone.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Krt19 antibody

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>19 publications with Krt19 and Adenocarcinoma
Liver Diseases Antibodies	>15 publications with Krt19 and Liver Diseases
Breast Neoplasms Antibodies	>14 publications with Krt19 and Breast Neoplasms
Neoplasm Metastasis Antibodies	>13 publications with Krt19 and Neoplasm Metastasis
Liver Neoplasms Antibodies	>9 publications with Krt19 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>8 publications with Krt19 and Carcinoma, Hepatocellular
Fibrosis Antibodies	>6 publications with Krt19 and Fibrosis
Liver Cirrhosis Antibodies	>5 publications with Krt19 and Liver Cirrhosis
Neoplasms, Experimental Antibodies	>5 publications with Krt19 and Neoplasms, Experimental
Neoplasm Invasiveness Antibodies	>5 publications with Krt19 and Neoplasm Invasiveness

Organs/Tissues associated with anti-Krt19 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>22 publications with Krt19 and Liver
Lung Antibodies	>7 publications with Krt19 and Lung
Eye Antibodies	>4 publications with Krt19 and Eye
Pancreas Antibodies	>4 publications with Krt19 and Pancreas
Thyroid Antibodies	>4 publications with Krt19 and Thyroid
Stomach Antibodies	>3 publications with Krt19 and Stomach
Embryonic Tissue Antibodies	>2 publications with Krt19 and Embryonic Tissue
Intestine Antibodies	>2 publications with Krt19 and Intestine
Bladder Antibodies	>1 publications with Krt19 and Bladder
Mammary Gland Antibodies	>1 publications with Krt19 and Mammary Gland