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CD194 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS223660

Rabbit anti mouse CD194 antibody recognizes mouse CD194, otherwise known as CCR4, C-C chemokine receptor type 4, C-C CKR-4or Cmkbr4. CD194 is a 360 amino acid ~42kDa transmembrane glycoprotein and member of the G-protein coupled receptor 1 family,… More details

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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CD194, Polyclonal Antibody
Full Product Name
RABBIT F(ab')2 ANTI MOUSE CD194
Product Gene Name
anti-CD194 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Purified
F(ab')2 fragment of purified IgG - liquid
Preparation and Storage
Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
41,408 Da
3D Structure
ModBase 3D Structure for P51680
Perservative Stabilisers
0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin
Buffer Solution
Phosphate buffered saline
Antiserum Preparation
Antiserum to mouse CD194 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Target Species
Mouse
Applications Tested/Suitable for anti-CD194 antibody
Immunohistology Frozen, ELISA (EIA), Flow cytometry (FC/FACS), Western Blot (WB)
Application Notes for anti-CD194 antibody
ELISA: This product is suitable for use in indirect ELISA applications.
Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Immunohistology - Frozen: Maximum Dilution: 1/300
ELISA: Maximum Dilution: 1/50000
Flow Cytometry: Maximum Dilution: 1/20
Western Blotting: Maximum Dilution: 1/1000

Other Notes

Small volumes of anti-CD194 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD194 purchase

MBS223660 is an antibody targeting CD194. Also known as RABBIT F(ab')2 ANTI MOUSE CD194. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD194. It may not necessarily be applicable to this product.

NCBI GI #
162287123
NCBI GeneID
12773
NCBI Accession #
NP_034046.2
UniProt Primary Accession #
P51680
UniProt Secondary Accession #
Q14A03
UniProt Related Accession #
P51680
GenBank Nucleotide #
NM_009916.2
NCBI Official Full Name
C-C chemokine receptor type 4
NCBI Official Synonym Full Names
chemokine (C-C motif) receptor 4
NCBI Official Symbol
Ccr4
NCBI Official Synonym Symbols
LESTR; Sdf1r; CHEMR1; Cmkbr4; C-C CKR-4
UniProt Protein Name
C-C chemokine receptor type 4
UniProt Synonym Protein Names
CD_antigen: CD194
Protein Family
C-C chemokine receptor
UniProt Gene Name
Ccr4
UniProt Synonym Gene Names
Cmkbr4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4
UniProt Entry Name
CCR4_MOUSE
NCBI Protein Information
C-C chemokine receptor type 4; chemokine (C-C) receptor 4; fusin; leukocyte-expressed seven-transmembrane-domain receptor

UniProt Comments for CD194

CCR4: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: membrane; cell soma; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; signal transducer activity; C-C chemokine receptor activity; chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of positive chemotaxis; neuron migration; immune response; chemotaxis; inflammatory response; signal transduction; tolerance induction
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Research Articles on CD194

1. NF-kappaB signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD194 antibody

 Reference Product  PubMed Publications
 Ccl17 antibody  >247 publications with CD194 and Ccl17
 Ccl22 antibody  >225 publications with CD194 and Ccl22
 Cxcr4 antibody  >150 publications with CD194 and Cxcr4
 Ccl5 antibody  >89 publications with CD194 and Ccl5
 Cxcl12 antibody  >42 publications with CD194 and Cxcl12
 Cxcl9 antibody  >25 publications with CD194 and Cxcl9
 Ccl20 antibody  >24 publications with CD194 and Ccl20
 Ccl25 antibody  >6 publications with CD194 and Ccl25
 Cxcl5 antibody  >4 publications with CD194 and Cxcl5
 Cxcl13 antibody  >3 publications with CD194 and Cxcl13

Pathways associated with anti-CD194 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with anti-CD194 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >276 publications with CD194 and Inflammation
 Lung Diseases Antibodies  >137 publications with CD194 and Lung Diseases
 Necrosis Antibodies  >83 publications with CD194 and Necrosis
 Carcinoma Antibodies  >38 publications with CD194 and Carcinoma
 Drug Hypersensitivity Antibodies  >37 publications with CD194 and Drug Hypersensitivity
 Fibrosis Antibodies  >30 publications with CD194 and Fibrosis
 Liver Diseases Antibodies  >21 publications with CD194 and Liver Diseases
 Neoplasms, Experimental Antibodies  >20 publications with CD194 and Neoplasms, Experimental
 Heart Diseases Antibodies  >19 publications with CD194 and Heart Diseases
 Lung Neoplasms Antibodies  >16 publications with CD194 and Lung Neoplasms

Organs/Tissues associated with anti-CD194 antibody

 Organ/Tissue Name  Pubmed Publications
 Thymus Antibodies  >157 publications with CD194 and Thymus
 Mixed Antibodies  >23 publications with CD194 and Mixed
 Embryonic Tissue Antibodies  >17 publications with CD194 and Embryonic Tissue
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