Rabbit Anti-CD234 Polyclonal Antibody – Cat# MBS223703

CD234 Antibody – Rabbit Polyclonal

Name: CD234 Antibody; Polyclonal; Rabbit; Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS223703
Price: 635 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS223703

MBS223703 detects CD234, also known as DARC, a multi-pass membrane protein belonging to the G protein coupled Duffy family. CD234 is a non-specific receptor for a number of cytokines including IL-8, GRO, RANTES, MCP-1 and TARC. CD234 also functions as the… More details

$635 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD234, Polyclonal Antibody

Full Product Name

RABBIT ANTI HUMAN CD234 (C-TERMINAL)

Product Gene Name

anti-CD234 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Reacts with: Mouse, Rat
N.B. Antibody reactivity and working conditions may vary between species.

Form/Format

Purified
Purified IgG - liquid

Concentration

IgG concentration 1.0mg/ml (lot specific)

Specificity

CD234 (C-Terminal)
This item detects CD234, also known as DARC, a multi-pass membrane protein belonging to the G protein coupled Duffy family.

CD234 is a non-specific receptor for a number of cytokines including IL-8, GRO, RANTES, MCP-1 and TARC. CD234 also functions as the receptor for the malaria parasites Plasmodium vivax and P. knowlesi.

CD234 is also responsible for the Duffy blood group system where a substitution at position 42 of either Gly-42 or Asp-42 results in Fy(A) or Fy(B).

CD234 is present in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along post capillary venules throughout the body, except in the adult liver. Erythroid cells and post capillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium.

It has been demonstrated that CD234 exists in multiple isoforms.

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

35,678 Da

OMIM

110700

3D Structure

ModBase 3D Structure for Q16570

Perservative Stabilisers

0.02% Sodium Azide (NaN3)

Immunogen

A peptide corresponding to a 16 amino acid sequence from near the carboxy terminus of Human CD234.

Histology Positive Control Tissue

Mouse brain tissue

Buffer Solution

Phosphate buffered saline

Antiserum Preparation

Antisera to Human CD234 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.

Target Species

Human

Applications Tested/Suitable for anti-CD234 antibody

Immunohistology Paraffin*, Western Blot (WB)

Application Notes for anti-CD234 antibody

Western Blot: This item detects bands of approximately 23 and 36kDa in Mouse brain tissue lysate.
Immunohistology - Paraffin: Maximum Dilution: 2.5ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 1.0; Maximum Dilution: 2.0ug/ml

Other Notes

Small volumes of anti-CD234 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD234 purchase

MBS223703 is an antibody targeting CD234. Also known as RABBIT ANTI HUMAN CD234 (C-TERMINAL). Reactive in Reacts with: Mouse, Rat
N.B. Antibody reactivity and working conditions may vary between species.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD234. It may not necessarily be applicable to this product.

NCBI GI #

171846251

NCBI GeneID

2532

NCBI Accession #

NP_001116423.1

UniProt Primary Accession #

Q16570

UniProt Secondary Accession #

O75898; Q16300; Q8WWE3; Q9UJP0; Q9UKZ5; Q9UKZ6; Q9UQE1; A8YPG5

UniProt Related Accession #

Q16570

GenBank Nucleotide #

NM_001122951.2

NCBI Official Full Name

atypical chemokine receptor 1 isoform a

NCBI Official Synonym Full Names

atypical chemokine receptor 1 (Duffy blood group)

NCBI Official Symbol

ACKR1

NCBI Official Synonym Symbols

FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1

UniProt Protein Name

Atypical chemokine receptor 1

UniProt Synonym Protein Names

Duffy antigen/chemokine receptor; Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor; CD_antigen: CD234

Protein Family

Atypical chemokine receptor

UniProt Gene Name

ACKR1

UniProt Synonym Gene Names

DARC; FY; GPD; GpFy

UniProt Entry Name

ACKR1_HUMAN

NCBI Protein Information

atypical chemokine receptor 1; Duffy blood group antigen; Duffy blood group, atypical chemokine receptor; Duffy blood group, chemokine receptor; Fy glycoprotein; glycoprotein D; plasmodium vivax receptor

NCBI Summary for CD234

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for CD234

DARC: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi. Belongs to the G-protein coupled receptor Duffy family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, Duffy family; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: recycling endosome; early endosome; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; transmembrane receptor activity; C-C chemokine binding; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; defense response; inflammatory response; regulation of chemokine production

Disease: White Blood Cell Count Quantitative Trait Locus 1; Blood Group, Duffy System; Malaria, Susceptibility To

Research Articles on CD234

1. Duffy blood group

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD234 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Other Pathway antibodies	GPCRs, Other Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Peptide GPCRs Pathway antibodies	Peptide GPCRs Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-CD234 antibody

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>1 publications with CD234 and Brain Diseases
Inflammation Antibodies	>1 publications with CD234 and Inflammation

Organs/Tissues associated with anti-CD234 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1 publications with CD234 and Brain