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Calretinin (CALB2) Antibody – Sheep Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS223868

MBS223868 recognises calretinin, a 29kDa calcium binding protein found mostly in the central nervous system and retina. It is a cytoplasmic protein involved in the regulation of calcium concentration, which is important in the regulation of a large variety of… More details

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Product Overview

Product Name
CALRETININ (CALB2), Polyclonal Antibody
Full Product Name
SHEEP ANTI GUINEA PIG CALRETININ
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Sheep
Species Reactivity
Human (Expected from Sequence), Mouse (Expected from Sequence), Primate (Expected from Sequence), Rat
Form/Format
Purified
Purified IgG - liquid
Specificity
This item recognises calretinin, a 29kDa calcium binding protein found mostly in the central nervous system and retina. It is a cytoplasmic protein involved in the regulation of calcium concentration, which is important in the regulation of a large variety of neuronal functions, including neurotransmitter release, ionic channel permeability, enzyme activity, and gene transcription. Mice deficient in calretinin show impairment in motor coordination.

Calretinin has also been shown as a sensitive and specific marker for mast cells.
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
31,540 Da
OMIM
114051
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Purified guinea pig calretinin
Buffer Solution||TRIS buffered saline
Antiserum Preparation
Antisera to Calretinin were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG was prepared from whole serum by Protein A chromatography.
Target Species
Guinea Pig
Applications Tested/Suitable for anti-CALB2 antibody
Immunohistology Frozen, Western Blot (WB)
Application Notes for anti-CALB2 antibody
Western Blot: This item detects a band of approximately 29kDa in rat cerebellum.
Immunohistology - Frozen: Maximum Dilution: 1/500
Western Blotting: Maximum Dilution: 1/1000

Other Notes

Small volumes of anti-CALB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CALB2 purchase

MBS223868 is an antibody targeting CALB2. Also known as SHEEP ANTI GUINEA PIG CALRETININ. Reactive in Human (Expected from Sequence), Mouse (Expected from Sequence), Primate (Expected from Sequence), Rat. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for CALB2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
calretinin isoform 1
NCBI Official Synonym Full Names
calbindin 2
NCBI Official Symbol
CALB2
NCBI Official Synonym Symbols
CR; CAL2; CAB29
UniProt Protein Name
Calretinin
UniProt Synonym Protein Names
29 kDa calbindin
Protein Family
UniProt Gene Name
CALB2
UniProt Synonym Gene Names
CAB29; CR
UniProt Entry Name
CALB2_HUMAN
NCBI Protein Information
calretinin; 29 kDa calbindin; calbindin 2, (29kD, calretinin); calbindin D29K

NCBI Summary for CALB2

This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
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UniProt Comments for CALB2

CALB2: Calretinin is a calcium-binding protein which is abundant in auditory neurons. Belongs to the calbindin family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: cytoplasm; gap junction; nucleus

Molecular Function: calcium ion binding

Biological Process: cytosolic calcium ion homeostasis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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