BAK Antibody – Rabbit Polyclonal

BAK1: In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. Interacts with BCL2A1. Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L). Interacts with myxoma virus protein M11L. Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle. Belongs to the Bcl-2 family.

Protein type: Mitochondrial; Endoplasmic reticulum; Membrane protein, integral; Apoptosis

Cellular Component: pore complex; membrane; mitochondrion; endoplasmic reticulum; cell; mitochondrial membrane; integral to membrane; intracellular; cytosol; integral to mitochondrial outer membrane

Molecular Function: identical protein binding; BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity; metal ion binding; heat shock protein binding; chaperone binding

Biological Process: response to fungus; regulation of protein heterodimerization activity; positive regulation of proteolysis; regulation of cell cycle; positive regulation of apoptosis; apoptosis; myeloid cell homeostasis; negative regulation of peptidyl-serine phosphorylation; homeostasis of number of cells; B cell apoptosis; regulation of apoptosis; negative regulation of cell proliferation; B cell homeostasis; regulation of mitochondrial membrane potential; response to gamma radiation; establishment and/or maintenance of transmembrane electrochemical gradient; B cell negative selection; leukocyte homeostasis; caspase activation; release of cytochrome c from mitochondria; response to mycotoxin; mitochondrial fusion; regulation of protein homodimerization activity; vagina development; limb morphogenesis; cell proliferation; DNA damage response, signal transduction resulting in induction of apoptosis; reduction of endoplasmic reticulum calcium ion concentration; blood vessel remodeling; caspase activation via cytochrome c; regulation of mitochondrial membrane permeability; post-embryonic camera-type eye morphogenesis