Rabbit Anti-GRM1 Polyclonal Antibody – Cat# MBS224070

Metabotropic Glutamate RECEPTOR 1a (GRM1) Antibody – Rabbit Polyclonal

Name: GRM1 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS224070
Price: 855 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS224070

MBS224070 recognises rat metabotropic glutamate receptor 1a (mGluR1a). The metabotropic glutamate receptors have been organised into three groups. mGluR5 and mGluR1 make up group I which, when activated, stimulates phospholipase C and activates protein kinase… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

METABOTROPIC GLUTAMATE RECEPTOR 1a (Grm1), Polyclonal Antibody

Full Product Name

RABBIT ANTI RAT METABOTROPIC GLUTAMATE RECEPTOR 1a

Product Gene Name

anti-Grm1 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Form/Format

Purified
Purified IgG - liquid

Specificity

This item recognises rat metabotropic glutamate receptor 1a (mGluR1a). The metabotropic glutamate receptors have been organised into three groups. mGluR5 and mGluR1 make up group I which, when activated, stimulates phospholipase C and activates protein kinase C to hydrolyse phosphoinositide phospholipids in the cell membrane. Group I mGluRs, but not other groups, are activated by 3, 5-dihydroxyphenylglycine (DHPG).

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

100,752 Da

3D Structure

ModBase 3D Structure for P23385

Perservative Stabilisers

0.09% Sodium Azide (NaN3)
0.01% Bovine Serum Albumin
50% Glycerol

Immunogen

Peptide corresponding to amino acids 1115-1130 from the C-terminal region of rat mGluR1a.
Buffer Solution||10mM HEPES pH7.5, 150mM NaCl

Antiserum Preparation

Antisera to metabotropic glutamate receptor 1a were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Target Species

Rat

Applications Tested/Suitable for anti-Grm1 antibody

Immunohistology Frozen, Western Blot (WB)

Application Notes for anti-Grm1 antibody

Western Blot: This item detects bands of approximately 125kDa (monomer) and 250kDa (dimer) on lysate from transfected HEK293 cells. This antibody has also been reported to detect bands at approximately 120kDa (reduced) and 210kD (non-reduced), in protein extracts from adult rat cerebellum.
Immunohistology - Frozen: Maximum Dilution: 1/500
Western Blotting: Maximum Dilution: 1/1000

Other Notes

Small volumes of anti-Grm1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Grm1 purchase

MBS224070 is an antibody targeting Grm1. Also known as RABBIT ANTI RAT METABOTROPIC GLUTAMATE RECEPTOR 1a. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Grm1. It may not necessarily be applicable to this product.

NCBI GI #

166999225

NCBI GeneID

24414

NCBI Accession #

NP_001107802.1

UniProt Primary Accession #

P23385

UniProt Related Accession #

P23385

GenBank Nucleotide #

NM_001114330.1

NCBI Official Full Name

metabotropic glutamate receptor 1 isoform beta

NCBI Official Synonym Full Names

glutamate receptor, metabotropic 1

NCBI Official Symbol

Grm1

NCBI Official Synonym Symbols

Gprc1a

UniProt Protein Name

Metabotropic glutamate receptor 1

Protein Family

Metabotropic glutamate receptor

UniProt Gene Name

Grm1

UniProt Synonym Gene Names

Gprc1a; Mglur1; mGluR1

UniProt Entry Name

GRM1_RAT

NCBI Protein Information

metabotropic glutamate receptor 1; G protein coupled receptor family C group 1 member A; mGluR1

NCBI Summary for Grm1

may play a role in synaptic transmission; may modulate perception of pain in arthritis [RGD, Feb 2006]

UniProt Comments for Grm1

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.

Research Articles on Grm1

1. Evidence for a similar mGluR1/mGluR5 functional dependence is shown in medium spiny striatal neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Grm1 antibody

Products by Pathway	Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies	Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Estrogen Signaling Pathway antibodies	Estrogen Signaling Pathway Diagram
Estrogen Signaling Pathway antibodies	Estrogen Signaling Pathway Diagram
FoxO Signaling Pathway antibodies	FoxO Signaling Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram

Diseases associated with anti-Grm1 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>15 publications with Grm1 and Nervous System Diseases
Brain Diseases Antibodies	>11 publications with Grm1 and Brain Diseases
Disease Models, Animal Antibodies	>11 publications with Grm1 and Disease Models, Animal
Movement Disorders Antibodies	>3 publications with Grm1 and Movement Disorders
Attention Deficit Disorder with Hyperactivity Antibodies	>3 publications with Grm1 and Attention Deficit Disorder with Hyperactivity
Tremor Antibodies	>2 publications with Grm1 and Tremor
Epilepsy Antibodies	>2 publications with Grm1 and Epilepsy
Cognition Disorders Antibodies	>1 publications with Grm1 and Cognition Disorders
Prenatal Exposure Delayed Effects Antibodies	>1 publications with Grm1 and Prenatal Exposure Delayed Effects
Fibroma Antibodies	>1 publications with Grm1 and Fibroma

Organs/Tissues associated with anti-Grm1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>23 publications with Grm1 and Brain