RITUXIMAB Antibody – Rat Monoclonal

Rat anti rituximab antibody, clone MB2A4, specifically recognizes the idiotypic determinants expressed by the rituximab chimeric monoclonal antibody.Rituximab is a therapeutic reagent directed against the human CD20 antigen expressed on the surface of B-cells. Rat anti rituximab antibody, clone MB2A4, is specific for rituximab and does not recognize other CD20 antibodies. Clone MB2A4 has been used in ELISA assays to monitor the levels of rituximab in patient serum following therapy, see Cragg, M. S. et al. and Hampson, G. et al. for details. Clone MB2A4 has been used to detect rituximab bound to the surface of the Raji B cell line, however detection of rituximab bound in vivo to B-CLL cells has not been demonstrated. It is possible that complement deposition on rituximab opsonised cells inhibits binding of the anti-rituximab antibody to cell bound rituximab (Beum, P. V. et al.).

Small volumes of anti-RITUXIMAB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS224427 is an antibody targeting RITUXIMAB. Also known as RAT ANTI RITUXIMAB:HRP. Host: Rat.