Mouse Anti-CD42a Monoclonal Antibody – Cat# MBS224431

Human peripheral blood platelets stained with Mouse anti Human CD42a:FITC (MBS224730)

CD42a Antibody – Mouse Monoclonal

Name: CD42a Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS224431
Price: 420 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS224431

Mouse anti Human CD42a antibody, clone FMC-25 recognizes human CD42a, also known as Platelet glycoprotein IX, Glycoprotein 9 or GP-IX. CD42a is a 177 amino acid, ~20kDa type I single pass transmembrane glycoprotein containing a single leucine-rich repeat… More details

$420 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD42a, Monoclonal Antibody

Full Product Name

MOUSE ANTI HUMAN CD42a

Product Gene Name

anti-CD42a antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

FMC-25

Host

Mouse

Form/Format

Purified
Purified IgG - liquid

Concentration

IgG concentration 1.0mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody.
Shelf Life: 12 months from date of receipt.

OMIM

173515

3D Structure

ModBase 3D Structure for P14770

Perservative Stabilisers

0.09% Sodium Azide (NaN₃)

Preparation

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Buffer Solution

Phosphate buffered saline.

Target Species

Human

Immunogen

Peripheral blood mononuclear cells.

Applications Tested/Suitable for anti-CD42a antibody

Immunohistology Frozen, Flow cytometry (FC)

Application Notes for anti-CD42a antibody

Flow Cytometry: Use 10ul of the suggested working dilution to label 1 x 10⁶ cells in 100ul.
Flow Cytometry: 1/50-1/200

Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls

Other Notes

Small volumes of anti-CD42a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD42a purchase

MBS224431 is an antibody targeting CD42a. Also known as MOUSE ANTI HUMAN CD42a. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD42a. It may not necessarily be applicable to this product.

NCBI GI #

4504077

NCBI GeneID

2815

NCBI Accession #

NP_000165.1

UniProt Primary Accession #

P14770

UniProt Secondary Accession #

Q14445; Q8N1D1; Q92525

UniProt Related Accession #

P14770

GenBank Nucleotide #

NM_000174.4

NCBI Official Full Name

platelet glycoprotein IX

NCBI Official Synonym Full Names

glycoprotein IX (platelet)

NCBI Official Symbol

GP9

NCBI Official Synonym Symbols

GPIX; CD42a

UniProt Protein Name

Platelet glycoprotein IX

UniProt Synonym Protein Names

Glycoprotein 9; CD_antigen: CD42a

Protein Family

Platelet glycoprotein

UniProt Gene Name

GP9

UniProt Synonym Gene Names

GP-IX; GPIX

UniProt Entry Name

GPIX_HUMAN

NCBI Protein Information

platelet glycoprotein IX; glycoprotein 9

NCBI Summary for CD42a

This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008]

UniProt Comments for CD42a

GPIX: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. Defects in GP9 are a cause of Bernard-Soulier syndrome (BSS); also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: integral to plasma membrane; plasma membrane

Biological Process: platelet activation; cell adhesion; blood coagulation; blood coagulation, intrinsic pathway

Disease: Bernard-soulier Syndrome

Research Articles on CD42a

1. genetic association study in population in western India: Data suggest novel mutations in platelet glycoprotein Ib (GP1BA, GP1BB) and GP9 are associated with Bernard-Soulier syndrome in subjects studies; of 12 mutations identified, ten were novel.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD42a antibody

Reference Product	PubMed Publications
GP1BB antibody	>4 publications with CD42a and GP1BB
GP1BA antibody	>4 publications with CD42a and GP1BA
GP5 antibody	>2 publications with CD42a and GP5

Pathways associated with anti-CD42a antibody

Products by Pathway	Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies	Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
GP1b-IX-V Activation Signalling Pathway antibodies	GP1b-IX-V Activation Signalling Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Intrinsic Pathway antibodies	Intrinsic Pathway Diagram
Platelet Adhesion To Exposed Collagen Pathway antibodies	Platelet Adhesion To Exposed Collagen Pathway Diagram
Platelet Aggregation (Plug Formation) Pathway antibodies	Platelet Aggregation (Plug Formation) Pathway Diagram

Diseases associated with anti-CD42a antibody

Disease Name	Pubmed Publications
Bernard-Soulier Syndrome Antibodies	>8 publications with CD42a and Bernard-Soulier Syndrome
Hematologic Diseases Antibodies	>5 publications with CD42a and Hematologic Diseases
Heart Defects, Congenital Antibodies	>1 publications with CD42a and Heart Defects, Congenital
Cardiovascular Diseases Antibodies	>1 publications with CD42a and Cardiovascular Diseases
Weight Loss Antibodies	>1 publications with CD42a and Weight Loss
Cell Transformation, Neoplastic Antibodies	>1 publications with CD42a and Cell Transformation, Neoplastic
Inflammation Antibodies	>1 publications with CD42a and Inflammation
Thrombocytopenia Antibodies	>1 publications with CD42a and Thrombocytopenia