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CD300a Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS224497

Mouse anti Human CD300a antibody, clone P192 specifically recognizes human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kDa transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes,… More details

$580 / 0.2 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD300a, Monoclonal Antibody
Full Product Name
MOUSE ANTI HUMAN CD300a
Product Gene Name
anti-CD300a antibody
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
P192
Host
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
16,517 Da
OMIM
606790
3D Structure
ModBase 3D Structure for Q9UGN4
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen
Polyclonal population of NK cells
Fusion Partners||Spleen cells from immunised mice were fused with cells of the P3U1 myeloma cell line.
Buffer Solution||Phosphate buffered saline
Target Species
Human
Applications Tested/Suitable for anti-CD300a antibody
Flow cytometry (FC/FACS)
Application Notes for anti-CD300a antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/200

Testing Data #1 of anti-CD300a antibody

Human peripheral blood monocytes stained with Mouse anti Human CD300a (MBS224497) followed by Rabbit F(ab')2 anti Mouse IgG:FITC (MBS235160)
Mouse Anti-CD300a Monoclonal Antibody – Cat# MBS224497

Testing Data #2 of anti-CD300a antibody

Human peripheral blood monocytes stained with Mouse anti Human CD300a:FITC (MBS224595)
Mouse Anti-CD300a Monoclonal Antibody, Testing Data #2 – Cat# MBS224497

Testing Data #3 of anti-CD300a antibody

Human peripheral blood monocytes stained with Mouse anti Human CD300a:RPE (MBS224739)
Mouse Anti-CD300a Monoclonal Antibody, Testing Data #3 – Cat# MBS224497

Other Notes

Small volumes of anti-CD300a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD300a purchase

MBS224497 is an antibody targeting CD300a. Also known as MOUSE ANTI HUMAN CD300a. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD300a. It may not necessarily be applicable to this product.

NCBI GI #
378786683
NCBI GeneID
11314
NCBI Accession #
NP_001243770.1
UniProt Primary Accession #
Q9UGN4
UniProt Secondary Accession #
O95100; Q9HD97; Q9P0F3; Q9UBK4; Q9UMS9; Q9UMT0; A8MW96
UniProt Related Accession #
Q9UGN4
GenBank Nucleotide #
NM_001256841.1
NCBI Official Full Name
CMRF35-like molecule 8 isoform 2
NCBI Official Synonym Full Names
CD300a molecule
NCBI Official Symbol
CD300A
NCBI Official Synonym Symbols
IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9
UniProt Protein Name
CMRF35-like molecule 8
UniProt Synonym Protein Names
CD300 antigen-like family member A; CMRF-35-H9; CMRF35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin superfamily member 12; IgSF12; Inhibitory receptor protein 60; IRp60; NK inhibitory receptor; CD_antigen: CD300a
Protein Family
CMRF35-like molecule
UniProt Gene Name
CD300A
UniProt Synonym Gene Names
CMRF35H; IGSF12; CLM-8; CMRF35-H9; IgSF12; IRp60
UniProt Entry Name
CLM8_HUMAN
NCBI Protein Information
CMRF35-like molecule 8; CD300 antigen-like family member A; CD300a antigen; CMRF35H leukocyte immunoglobulin-like receptor; NK inhibitory receptor; immunoglobulin superfamily member 12; inhibitory receptor protein 60; leukocyte membrane antigen

NCBI Summary for CD300a

This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
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UniProt Comments for CD300a

MAIR-I: Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Belongs to the CD300 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; phosphatidylethanolamine binding; phosphatidylserine binding

Biological Process: positive regulation of phosphoprotein phosphatase activity; negative regulation of MAP kinase activity; negative regulation of NK T cell activation; immune system process; negative regulation of mast cell degranulation; negative regulation of mast cell activation during immune response; negative regulation of B cell proliferation; signal transduction; negative regulation of phagocytosis, engulfment; negative regulation of B cell receptor signaling pathway; negative regulation of fibroblast proliferation; regulation of T cell receptor signaling pathway; cell adhesion
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Research Articles on CD300a

1. The inhibitory receptor CD300a is regulator of monocytes transendothelial migration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD300a antibody

 Reference Product  PubMed Publications
 ITGB2 antibody  >1 publications with CD300a and ITGB2

Diseases associated with anti-CD300a antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >14 publications with CD300a and Inflammation
 Death Antibodies  >4 publications with CD300a and Death
 Disease Models, Animal Antibodies  >3 publications with CD300a and Disease Models, Animal
 Lung Diseases Antibodies  >2 publications with CD300a and Lung Diseases
 Psoriasis Antibodies  >1 publications with CD300a and Psoriasis
 Metaplasia Antibodies  >1 publications with CD300a and Metaplasia
 Colitis Antibodies  >1 publications with CD300a and Colitis
 Learning Disorders Antibodies  >1 publications with CD300a and Learning Disorders
 Fibrosis Antibodies  >1 publications with CD300a and Fibrosis
 Necrosis Antibodies  >1 publications with CD300a and Necrosis

Organs/Tissues associated with anti-CD300a antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >31 publications with CD300a and Blood
 Spleen Antibodies  >2 publications with CD300a and Spleen
 Lung Antibodies  >2 publications with CD300a and Lung
 Thymus Antibodies  >1 publications with CD300a and Thymus
 Muscle Antibodies  >1 publications with CD300a and Muscle
 Bone Antibodies  >1 publications with CD300a and Bone
 Brain Antibodies  >1 publications with CD300a and Brain
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