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CD266 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS224691

Mouse anti Human CD266 antibody, clone ITEM-4 recognizes human CD266, otherwise known as Fn14/TWEAK Receptor, a 14kDa type I transmembrane glycoprotein and member of the tumour necrosis factor receptor superfamily (TNFRSF12A) expressed by a variety of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CD266, Monoclonal Antibody
Full Product Name
MOUSE ANTI HUMAN CD266
Product Gene Name
anti-CD266 antibody
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
ITEM-4
Host
Mouse
Species Reactivity
Mouse, Rat
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
10,191 Da
OMIM
605914
3D Structure
ModBase 3D Structure for Q9NP84
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen
Human CD266 transfected P815 cells
Fusion Partners||Spleen cells from immunised BALB/c mice were fused with cells of the P3U1 mouse myeloma cell line.
Buffer Solution||Phosphate buffered saline
Target Species
Human
Applications Tested/Suitable for anti-CD266 antibody
Immunohistology Frozen, Flow cytometry (FC/FACS), Western Blot (WB)
Application Notes for anti-CD266 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/200

Testing Data #1 of anti-CD266 antibody

Human CD266 transfected cells stained with Mouse anti Human CD266 (MBS224691) followed by Rabbit F(ab')2 anti Mouse IgG:RPE (MBS235280)
Mouse Anti-CD266 Monoclonal Antibody – Cat# MBS224691

Testing Data #2 of anti-CD266 antibody

Human CD266 transfected cells stained with Mouse anti Human CD266:FITC (MBS224675)
Mouse Anti-CD266 Monoclonal Antibody, Testing Data #2 – Cat# MBS224691

Testing Data #3 of anti-CD266 antibody

Human CD266 transfected cells stained with Mouse anti Human CD266: Alexa FluorR488 (MBS224691)
Mouse Anti-CD266 Monoclonal Antibody, Testing Data #3 – Cat# MBS224691

Testing Data #4 of anti-CD266 antibody

Human CD266 transfected cells stained with Mouse anti Human CD266: Alexa FluorR647 (MBS224691)
Mouse Anti-CD266 Monoclonal Antibody, Testing Data #4 – Cat# MBS224691

Testing Data #5 of anti-CD266 antibody

Human CD266 transfected cells stained with Mouse anti Human CD266:RPE (MBS224572)
Mouse Anti-CD266 Monoclonal Antibody, Testing Data #5 – Cat# MBS224691

Other Notes

Small volumes of anti-CD266 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD266 purchase

MBS224691 is an antibody targeting CD266. Also known as MOUSE ANTI HUMAN CD266. Reactive in Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD266. It may not necessarily be applicable to this product.

NCBI GI #
7706186
NCBI GeneID
51330
NCBI Accession #
NP_057723.1
UniProt Primary Accession #
Q9NP84
UniProt Secondary Accession #
Q9HCS0; D3DUA6
UniProt Related Accession #
Q9NP84
GenBank Nucleotide #
NM_016639.2
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 12A
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 12A
NCBI Official Symbol
TNFRSF12A
NCBI Official Synonym Symbols
FN14; CD266; TWEAKR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 12A
UniProt Synonym Protein Names
Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD_antigen: CD266
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF12A
UniProt Synonym Gene Names
FN14; FGF-inducible 14; TweakR
UniProt Entry Name
TNR12_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 12A; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; tweak-receptor; type I transmembrane protein Fn14

UniProt Comments for CD266

TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: ruffle; cell surface; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: positive regulation of apoptosis; substrate-bound cell migration, cell attachment to substrate; positive regulation of axon extension; angiogenesis; regulation of angiogenesis
Show more

Research Articles on CD266

1. Results position TWEAK-Fn14 signaling through Mcl-1 as a significant mechanism for NSCLC tumor cell survival

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD266 antibody

 Reference Product  PubMed Publications
 TNFSF12 antibody  >5 publications with CD266 and TNFSF12
 TNFRSF25 antibody  >1 publications with CD266 and TNFRSF25

Pathways associated with anti-CD266 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 TWEAK Signaling Pathway antibodies  TWEAK Signaling Pathway Diagram

Diseases associated with anti-CD266 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >14 publications with CD266 and Necrosis
 Inflammation Antibodies  >9 publications with CD266 and Inflammation
 Neoplasms, Experimental Antibodies  >4 publications with CD266 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >3 publications with CD266 and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with CD266 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >3 publications with CD266 and Adenocarcinoma
 Lung Diseases Antibodies  >3 publications with CD266 and Lung Diseases
 Heart Diseases Antibodies  >2 publications with CD266 and Heart Diseases
 Disease Models, Animal Antibodies  >2 publications with CD266 and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with CD266 and Breast Neoplasms

Organs/Tissues associated with anti-CD266 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >7 publications with CD266 and Vascular
 Lung Antibodies  >7 publications with CD266 and Lung
 Muscle Antibodies  >5 publications with CD266 and Muscle
 Blood Antibodies  >4 publications with CD266 and Blood
 Eye Antibodies  >3 publications with CD266 and Eye
 Kidney Antibodies  >2 publications with CD266 and Kidney
 Heart Antibodies  >2 publications with CD266 and Heart
 Bone Antibodies  >2 publications with CD266 and Bone
 Brain Antibodies  >1 publications with CD266 and Brain
 Intestine Antibodies  >1 publications with CD266 and Intestine
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