Peroxiredoxin 4 (PRDX4) Antibody – Mouse Monoclonal

Monoclonal

IgG2b

CPTC-PRDX4-2

Mouse

Human

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX IV gene is expressed in many tissues. It exists as a precursor protein, which is only detected in testis, and aprocessed secreted form. PRX IV is highly expressed in lung cancer and is necessary for the promotion of lung cancer in vitro. Studies have demonstrated that PRX IV positive expression is significantly correlated with recurrences and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma, and therefore can be used as a prognostic marker in lung squamous cell carcinoma.

Antibody with azide - store at 2 to 8°C.
Antibody without azide - store at -20 to -80°C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

27kDa

ModBase 3D Structure for Q13162

Recombinant human full-length PRDX4 protein

HepG2, HeLa and Jurkat cell lysates, ovarian carcinoma tissue. HePG2

Cytoplasm. Secreted.

Cardiovascular, Immunology