NOTCH 1 Antibody – Rabbit Polyclonal

Notch 1: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Heterodimer of a C-terminal fragment N(TM) and an N- terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiation. In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues. Belongs to the NOTCH family.

Protein type: Transcription factor; Motility/polarity/chemotaxis; Oncoprotein; Membrane protein, integral; Receptor, misc.

Cellular Component: acrosome; adherens junction; apical plasma membrane; cell surface; cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; Golgi apparatus; integral to membrane; integral to plasma membrane; membrane; nucleus; plasma membrane; receptor complex

Molecular Function: calcium ion binding; chromatin binding; chromatin DNA binding; enzyme binding; enzyme inhibitor activity; metal ion binding; Notch binding; protein binding; protein heterodimerization activity; receptor activity; sequence-specific DNA binding; transcription factor activity

Biological Process: activation of Notch receptor target transcription factor; anagen; angiogenesis; astrocyte differentiation; auditory receptor cell fate commitment; axonogenesis; branching morphogenesis of a tube; cardiac muscle cell proliferation; cardiac muscle morphogensis; cell differentiation; cell fate commitment; cell fate specification; compartment specification; determination of left/right symmetry; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; endoderm development; epidermis development; epithelial to mesenchymal transition; forebrain development; foregut morphogenesis; glial cell differentiation; hair follicle morphogenesis; heart development; heart looping; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; keratinocyte differentiation; liver development; lumen formation; lung development; mesenchymal cell development; multicellular organismal development; negative regulation of auditory receptor cell differentiation; negative regulation of BMP signaling pathway; negative regulation of calcium ion-dependent exocytosis; negative regulation of catalytic activity; negative regulation of cell differentiation; negative regulation of cell proliferation; negative regulation of myoblast differentiation; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of photoreceptor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neural tube development; neuron differentiation; neuron fate commitment; Notch signaling pathway; osteoblast fate commitment; positive regulation of apoptosis; positive regulation of astrocyte differentiation; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell proliferation; positive regulation of glial cell differentiation; positive regulation of JAK-STAT cascade; positive regulation of keratinocyte differentiation; positive regulation of neuroblast proliferation; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of viral genome replication; positive regulation of viral transcription; regulation of auditory receptor cell differentiation; regulation of cell migration; regulation of cell proliferation; regulation of developmental process; regulation of epithelial cell proliferation; regulation of gene expression; regulation of neurogenesis; regulation of Notch signaling pathway; regulation of somitogenesis; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to muramyl dipeptide; somatic stem cell division; spermatogenesis; sprouting angiogenesis; transcription, DNA-dependent