PAK4 Antibody – Rabbit Polyclonal

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PAK4: a protein kinase of the STE20 family. A mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Interacts specifically with the GTP-bound form of Cdc42 and weakly activates the JNK family of MAP kinases. Overexpressed in several cancers. Required for ras-dependent anchorage-independent growth of tumor cell lines. Four alternatively spliced human isoforms have been reported.

Protein type: Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; STE group; STE20 family; PAKB subfamily

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: focal adhesion; Golgi apparatus

Molecular Function: ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding

Biological Process: actin cytoskeleton organization and biogenesis; activation of protein kinase activity; apoptosis; cell cycle; cell growth; cell migration; cell motility; cell proliferation; cytoskeleton organization and biogenesis; regulation of apoptosis; regulation of MAPKKK cascade; regulation of mitotic cell cycle; regulation of transcription, DNA-dependent; Rho protein signal transduction; signal transduction; stress-activated protein kinase signaling pathway