CREB1 Antibody – Rabbit Polyclonal

CREB: a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Transcription factor

Cellular Component: axon; chromatin; mitochondrial matrix; mitochondrion; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function: DNA binding; double-stranded DNA binding; enzyme binding; histone acetyltransferase binding; Hsp70 protein binding; identical protein binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: aging; axonogenesis; circadian rhythm; lactation; mammary gland development; memory; pituitary gland development; positive regulation of apoptosis; positive regulation of fat cell differentiation; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; positive regulation of multicellular organism growth; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcriptional preinitiation complex assembly; positive regulation of transforming growth factor-beta3 production; protein amino acid phosphorylation; protein stabilization; regulation of apoptosis; regulation of cell size; regulation of circadian rhythm; regulation of fibroblast proliferation; regulation of transcription, DNA-dependent; response to activity; response to drug; response to glucagon stimulus; response to hypoxia; response to nicotine; response to organic substance; secretory granule organization and biogenesis; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; visual learning