PDKP1 Antibody – Rabbit Polyclonal

PDK1: an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described.

Protein type: Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; AGC group; PKB family

Cellular Component: cell junction; cell projection; cytoplasm; cytoplasmic membrane-bound vesicle; cytosol; membrane; nucleus; perikaryon; plasma membrane

Molecular Function: 3-phosphoinositide-dependent protein kinase activity; ATP binding; insulin receptor binding; kinase activity; nucleotide binding; phospholipase activator activity; phospholipase binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; transferase activity

Biological Process: activation of protein kinase B; calcium-mediated signaling; cell migration; cellular response to insulin stimulus; epidermal growth factor receptor signaling pathway; focal adhesion formation; hyperosmotic response; negative regulation of neuron apoptosis; negative regulation of protein kinase activity; negative regulation of toll-like receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; protein amino acid phosphorylation; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of mast cell degranulation; regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent