JIP1 Antibody – Rabbit Polyclonal

JIP1: a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade. Required for JNK activation in response to excitotoxic stress. Causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and by inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly or indirectly regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins.

Protein type: Adaptor/scaffold

Cellular Component: axon; cytoplasm; cytosol; dendrite; endoplasmic reticulum; membrane; mitochondrion; neuron projection; nucleus; perinuclear region of cytoplasm; synapse

Molecular Function: identical protein binding; JUN kinase binding; kinesin binding; MAP-kinase scaffold activity; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein kinase binding

Biological Process: JUN phosphorylation; negative regulation of apoptosis; negative regulation of JNK activity; negative regulation of JNK cascade; regulation of JNK cascade; regulation of transcription, DNA-dependent; signal transduction; vesicle-mediated transport