Deacetylase 6 (HDAC6) Antibody – Rabbit Polyclonal

HDAC6: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily.

Protein type: Nuclear receptor co-regulator; Deacetylase; Ubiquitin conjugating system; EC 3.5.1.98

Cellular Component: axon; caveola; cell projection; centrosome; cytoplasm; cytoplasmic microtubule; cytosol; dendrite; dynein complex; histone deacetylase complex; inclusion body; leading edge; microtubule; microtubule associated complex; neuron projection; nucleus; perikaryon; perinuclear region of cytoplasm; protein complex

Molecular Function: actin binding; alpha-tubulin binding; beta-catenin binding; beta-tubulin binding; histone deacetylase activity; histone deacetylase binding; Hsp90 protein binding; hydrolase activity; metal ion binding; microtubule binding; misfolded protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); polyubiquitin binding; protein binding; tau protein binding; tubulin deacetylase activity; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding

Biological Process: chromatin modification; collateral sprouting; histone deacetylation; intracellular protein transport; lysosome localization; macroautophagy; misfolded or incompletely synthesized protein catabolic process; mitochondrion localization; negative regulation of microtubule depolymerization; negative regulation of protein complex disassembly; negative regulation of proteolysis; positive regulation of signal transduction; protein amino acid deacetylation; protein complex disassembly; protein polyubiquitination; regulation of fat cell differentiation; regulation of gene expression, epigenetic; regulation of protein stability; regulation of receptor activity; regulation of transcription, DNA-dependent; response to misfolded protein; response to organic substance; response to toxin; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process via the multivesicular body pathway