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Interacting KILLER (BCL-2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS224955

Rabbit anti Bcl-2 interacting killer antibody recognizes Bcl-2-interacting killer, also known as BLK. Bcl-2 interacting killer plays a role in mediating apoptotic responses via interaction with Bcl-2 and Bcl-xL. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Bcl-2 INTERACTING KILLER, Polyclonal Antibody
Full Product Name
RABBIT ANTI Bcl-2 INTERACTING KILLER
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Purified IgG - liquid
Concentration
IgG concentration 0.2 mg/ml (lot specific)
Specificity
Bcl-2 INTERACTING KILLER
Preparation and Storage
Store at -20 degree C Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch
Molecular Weight
18,016 Da
OMIM
603392
Preservative Stabilisers
50% Glycerol, 1% Bovine Serum Albumin, 0.02% Thiomersal
Buffer Solution
Phosphate buffered saline
Applications Tested/Suitable for anti-Bcl-2 antibody
Western Blot (WB)
Application Notes for anti-Bcl-2 antibody
Western Blot: 0.5; 4.0 ug/ml

Western Blot (WB) of anti-Bcl-2 antibody

Western blot analysis of mouse kidney tissue lysate probed with Rabbit anti Bcl-2 interacting killer antibody
Rabbit Anti-BCL-2 Polyclonal Antibody – Cat# MBS224955

Other Notes

Small volumes of anti-Bcl-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Bcl-2 purchase

MBS224955 is an antibody targeting Bcl-2. Also known as RABBIT ANTI Bcl-2 INTERACTING KILLER. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Bcl-2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
bcl-2-interacting killer
NCBI Official Synonym Full Names
BCL2-interacting killer
NCBI Official Symbol
BIK
NCBI Official Synonym Symbols
BP4; NBK; BIP1
UniProt Protein Name
Bcl-2-interacting killer
UniProt Synonym Protein Names
Apoptosis inducer NBK; BIP1; BP4
UniProt Gene Name
BIK
UniProt Synonym Gene Names
NBK
UniProt Entry Name
BIK_HUMAN
NCBI Protein Information
bcl-2-interacting killer

NCBI Summary for Bcl-2

The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]
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UniProt Comments for Bcl-2

BIK: accelerates programmed cell death. Binding to the apoptosis repressors Bcl-xL, Bcl-2, or BHRF1 (the Epstein-Barr virus homolog of Bcl-2) suppresses its death-promoting activity. Contains 1 Bcl-2 homology 3 (BH3) domain. Does not interact with Bax.

Protein type: Mitochondrial; Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: endomembrane system; integral to membrane; mitochondrial membrane

Molecular Function: BH domain binding; protein binding; protein heterodimerization activity

Biological Process: apoptosis; apoptotic mitochondrial changes; male gonad development; positive regulation of protein homooligomerization; spermatogenesis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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