CD95/FAS Antibody – Rabbit Polyclonal

FAS: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine

Cellular Component: apical plasma membrane; CD95 death-inducing signaling complex; cell soma; cell surface; cytoplasm; external side of plasma membrane; extracellular region; extracellular space; integral to membrane; integral to plasma membrane; lipid raft; membrane; neuron projection; nucleus; perinuclear region of cytoplasm; plasma membrane; sarcolemma; secretory granule

Molecular Function: identical protein binding; kinase binding; protease binding; protein binding; protein complex binding; transmembrane receptor activity; tumor necrosis factor receptor activity

Biological Process: activated T cell apoptosis; apoptosis; B cell mediated immunity; brain development; dendrite regeneration; gene expression; immune response; immunoglobulin production; induction of apoptosis via death domain receptors; inflammatory cell apoptosis; inflammatory response; negative regulation of apoptosis; negative regulation of B cell activation; negative thymic T cell selection; neuron apoptosis; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of MAPKKK cascade; positive regulation of protein homooligomerization; protein homooligomerization; regulation of apoptosis; regulation of caspase activity; regulation of cell proliferation; regulation of gene expression; regulation of lymphocyte differentiation; regulation of myeloid cell differentiation; renal system process; response to glucocorticoid stimulus; response to lipopolysaccharide; response to toxin; signal transduction; spleen development; T cell homeostasis; transformed cell apoptosis; tumor necrosis factor-mediated signaling pathway