PHLDA3 Antibody – Rabbit

PHLDA3: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor. Belongs to the PHLDA3 family. Induced by p53/TP53; expression is directly activated by p53/TP53. p53/TP53 phosphorylation on 'Ser-15' is required to activate the PHLDA3 promoter.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: cytoplasm; plasma membrane

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-5-phosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol 3-phosphate binding

Biological Process: anatomical structure morphogenesis; negative regulation of protein kinase B signaling cascade; positive regulation of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis