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CARD11 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS225088

Rabbit anti CARD11 antibody recognizes caspase recruitment domain-containing protein 11 (CARD11), also known as CARMA1. CARD11 is part of both the membrane associated guanylate kinase (MAGUK) family and the caspase recruitment domain (CARD) family. CARD11 is… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
CARD11, Polyclonal Antibody
Full Product Name
Rabbit anti CARD11
Product Gene Name
Product Synonym Names
CARD11 Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.
Purity/Purification
Purified whole serum by affinity chromatography.
Preparation and Storage
Store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch
Molecular Weight
133,284 Da
OMIM
607210
3D Structure
ModBase 3D Structure for Q9BXL7
Immunogen
Recombinant human CARD11
Preperation
Antiserum to CARD11 was raised by repeated immunization of rabbits with highly purified antigen.
Applications Tested/Suitable for anti-CARD11 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-CARD11 antibody
IHC-Paraffin: 1:50-1:200
WB: 1:500-1:2000

Western Blot (WB) of anti-CARD11 antibody

Western blot analysis of Raji cell lysate and mouse tissue lysate using Rabbit anti CARD11 antibody
Rabbit Anti-CARD11 Polyclonal Antibody – Cat# MBS225088

Immunohistochemistry (IHC) of anti-CARD11 antibody

Immunohistochemistry of paraffin-embedded human liver injury using Rabbit anti CARD11 antibody at a dilution of 1/100
Rabbit Anti-CARD11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS225088

Other Notes

Small volumes of anti-CARD11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CARD11 purchase

MBS225088 is an antibody targeting CARD11. Also known as Rabbit anti CARD11. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CARD11. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Caspase recruitment domain-containing protein 11
NCBI Official Synonym Full Names
caspase recruitment domain family member 11
NCBI Official Symbol
CARD11
NCBI Official Synonym Symbols
PPBL; BENTA; BIMP3; IMD11; CARMA1; IMD11A
UniProt Protein Name
Caspase recruitment domain-containing protein 11
UniProt Synonym Protein Names
CARD-containing MAGUK protein 1; Carma 1
UniProt Gene Name
CARD11
UniProt Synonym Gene Names
; Carma 1
NCBI Protein Information
caspase recruitment domain-containing protein 11

NCBI Summary for CARD11

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]
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UniProt Comments for CARD11

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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