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IKK Gamma (IKBKG) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS225122

Rabbit anti IKK gamma antibody recognizes IKK gamma, also known as NF-kappa-B essential modulator (NEMO), IKBKG and inhibitor of nuclear factor kappa-B kinase subunit gamma. IKK gamma is the regulatory subunit of the inhibitor of IkB kinase complex which… More details

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Product Overview

Product Name
IKK Gamma (IKBKG), Polyclonal Antibody
Full Product Name
Rabbit anti IKK Gamma
Product Gene Name
Product Synonym Names
IKK Gamma Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.
Purity/Purification
Purified whole serum by affinity chromatography.
Preparation and Storage
Store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch
Molecular Weight
36,953 Da
OMIM
300248
3D Structure
ModBase 3D Structure for Q9Y6K9
Immunogen
Recombinant human IKK gamma
Preperation
Antiserum to IKK gamma was raised by repeated immunization of rabbits with highly purified antigen.
Applications Tested/Suitable for anti-IKBKG antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-IKBKG antibody
IHC-Paraffin: 1:50-1:100
WB: 1:500-1:2000

Western Blot (WB) of anti-IKBKG antibody

Western blot analysis of cell and tissue lysates using Rabbit anti IKK gamma antibody
Rabbit Anti-IKBKG Polyclonal Antibody – Cat# MBS225122

Immunohistochemistry (IHC) of anti-IKBKG antibody

Immunohistochemistry of paraffin-embedded human liver cancer using Rabbit anti IKK gamma antibody at a dilution of 1/100
Rabbit Anti-IKBKG Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS225122

Immunohistochemistry (IHC) of anti-IKBKG antibody

Immunohistochemistry of paraffin-embedded rat heart using Rabbit anti IKK gamma antibody
Rabbit Anti-IKBKG Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS225122

Immunohistochemistry (IHC) of anti-IKBKG antibody

Immunohistochemistry of paraffin-embedded rat brain using Rabbit anti IKK gamma antibody
Rabbit Anti-IKBKG Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS225122

Other Notes

Small volumes of anti-IKBKG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IKBKG purchase

MBS225122 is an antibody targeting IKBKG. Also known as Rabbit anti IKK Gamma. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IKBKG. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
NF-kappa-B essential modulator
NCBI Official Synonym Full Names
inhibitor of nuclear factor kappa B kinase subunit gamma
NCBI Official Symbol
IKBKG
NCBI Official Synonym Symbols
IP; IP1; IP2; FIP3; IKKG; IPD2; NEMO; FIP-3; Fip3p; IMD33; AMCBX1; IKKAP1; ZC2HC9; IKK-gamma
UniProt Protein Name
NF-kappa-B essential modulator
UniProt Synonym Protein Names
FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifier
UniProt Gene Name
IKBKG
UniProt Synonym Gene Names
FIP3; NEMO; NEMO; IKKAP1; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma
NCBI Protein Information
NF-kappa-B essential modulator

NCBI Summary for IKBKG

This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]
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UniProt Comments for IKBKG

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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