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IRF8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS225127

Rabbit anti IRF8 antibody recognizes IRF8, also known as interferon regulatory factor 8, interferon consensus sequence-binding protein and ICSBP. IRF8 is a member of the interferon regulatory factor (IRF) family of transcription factors. IRF family proteins… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IRF8, Polyclonal Antibody
Full Product Name
Rabbit anti IRF8
Product Gene Name
Product Synonym Names
IRF8 Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.
Purity/Purification
Purified whole serum by affinity chromatography.
Preparation and Storage
Store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch
Molecular Weight
48,356 Da
OMIM
601565
3D Structure
ModBase 3D Structure for Q02556
Immunogen
Recombinant human IRF8
Preperation
Antiserum to IRF8 was raised by repeated immunization of rabbits with highly purified antigen.
Applications Tested/Suitable for anti-IRF8 antibody
Western Blot (WB)
Application Notes for anti-IRF8 antibody
WB: 1:500-1:2000

Western Blot (WB) of anti-IRF8 antibody

Western blot analysis of cell and tissue lysates using Rabbit anti IRF8 antibody
Rabbit Anti-IRF8 Polyclonal Antibody – Cat# MBS225127

Other Notes

Small volumes of anti-IRF8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IRF8 purchase

MBS225127 is an antibody targeting IRF8. Also known as Rabbit anti IRF8. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IRF8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Interferon regulatory factor 8
NCBI Official Synonym Full Names
interferon regulatory factor 8
NCBI Official Symbol
IRF8
NCBI Official Synonym Symbols
ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP
UniProt Protein Name
Interferon regulatory factor 8
UniProt Synonym Protein Names
Interferon consensus sequence-binding protein; H-ICSBP; ICSBP
UniProt Gene Name
IRF8
UniProt Synonym Gene Names
ICSBP1; IRF-8; H-ICSBP; ICSBP
NCBI Protein Information
interferon regulatory factor 8

NCBI Summary for IRF8

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
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UniProt Comments for IRF8

Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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