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Phospholipase C-GAMMA-2 (PLCG2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS225151

Rabbit anti phospholipase C-gamma-2 antibody recognizes phospholipase C-gamma-2 also known as PLCG2. Phospholipase C is a family of enzymes that cleave phospholipids producing molecules (DAG & IP3) that induce further downstream signaling. More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
Phospholipase C-GAMMA-2 (PLCG2), Polyclonal Antibody
Full Product Name
Rabbit anti Phospholipase C-GAMMA-2
Product Gene Name
Product Synonym Names
Phospholipase C-GAMMA-2 Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat (Expected from Sequence)
Form/Format
Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.
Purity/Purification
Purified whole serum by affinity chromatography.
Preparation and Storage
Store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch
Molecular Weight
147,870 Da
OMIM
600220
3D Structure
ModBase 3D Structure for P16885
Immunogen
Recombinant human phospholipase C-gamma-2
Preperation
Antiserum to phospholipase C-gamma-2 was raised by repeated immunization of rabbits with highly purified antigen.
Applications Tested/Suitable for anti-PLCG2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-PLCG2 antibody
IHC-Paraffin: 1:50-1:200
WB: 1:500-1:2000

Western Blot (WB) of anti-PLCG2 antibody

Western blot analysis of cell lysates using Rabbit anti phospholipase C-gamma-2 antibody
Rabbit Anti-PLCG2 Polyclonal Antibody – Cat# MBS225151

Immunohistochemistry (IHC) of anti-PLCG2 antibody

Immunohistochemistry of paraffin-embedded mouse heart using Rabbit anti phospholipase C-gamma-2 antibody at a dilution of 1/100
Rabbit Anti-PLCG2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS225151

Other Notes

Small volumes of anti-PLCG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLCG2 purchase

MBS225151 is an antibody targeting PLCG2. Also known as Rabbit anti Phospholipase C-GAMMA-2. Reactive in Human, Mouse, Rat (Expected from Sequence). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PLCG2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
NCBI Official Synonym Full Names
phospholipase C gamma 2
NCBI Official Symbol
PLCG2
NCBI Official Synonym Symbols
FCAS3; APLAID; PLC-IV; PLC-gamma-2
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
UniProt Synonym Protein Names
Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2
UniProt Gene Name
PLCG2
UniProt Synonym Gene Names
PLC-IV; PLC-gamma-2
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

NCBI Summary for PLCG2

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
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UniProt Comments for PLCG2

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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