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Vimentin (VIM) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS225177

Rabbit anti vimentin antibody recognizes vimentin, a protein belonging to the intermediate filament family. Vimentin is ubiquitously expressed in mesenchymal cells and plays a role in supporting and anchoring of organelles in the cytosol. More details

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Product Overview

Product Name
Vimentin, Polyclonal Antibody
Full Product Name
Rabbit anti Vimentin
Product Gene Name
anti-VIM antibody
Product Synonym Names
Vimentin Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse (Expected from Sequence), Rat (Expected from Sequence)
Form/Format
Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.
Purity/Purification
Purified whole serum by affinity chromatography.
Preparation and Storage
Store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch
Molecular Weight
53,652 Da
OMIM
116300
3D Structure
ModBase 3D Structure for P08670
Immunogen
Recombinant human vimentin
Preperation
Antiserum to vimentin was raised by repeated immunization of rabbits with highly purified antigen.
Applications Tested/Suitable for anti-VIM antibody
Western Blot (WB)
Application Notes for anti-VIM antibody
WB: 1:500-1:1000

Western Blot (WB) of anti-VIM antibody

Western blot analysis of cell lysates using Rabbit anti vimentin antibody
Rabbit Anti-VIM Polyclonal Antibody – Cat# MBS225177

Other Notes

Small volumes of anti-VIM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VIM purchase

MBS225177 is an antibody targeting VIM. Also known as Rabbit anti Vimentin. Reactive in Human, Mouse (Expected from Sequence), Rat (Expected from Sequence). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for VIM. It may not necessarily be applicable to this product.

NCBI GI #
55977767
NCBI GeneID
7431
NCBI Accession #
P08670.4
UniProt Primary Accession #
P08670
UniProt Secondary Accession #
Q15867; Q15868; Q15869; Q548L2; Q6LER9; Q8N850; Q96ML2; Q9NTM3; B0YJC2; D3DRU4
UniProt Related Accession #
P08670
NCBI Official Full Name
Vimentin
NCBI Official Synonym Full Names
vimentin
NCBI Official Symbol
VIM
UniProt Protein Name
Vimentin
Protein Family
Vimentin
UniProt Gene Name
VIM
NCBI Protein Information
vimentin

NCBI Summary for VIM

This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients. [provided by RefSeq, Aug 2017]
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UniProt Comments for VIM

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

Research Articles on VIM

1. our results demonstrated that vimentin in human GC tissues and cell lines was upregulated due to its de-ubiquitination after interactions with USP14 and miR-320a, which could promote the aggressiveness of GC cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-VIM antibody

 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram

Diseases associated with anti-VIM antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >418 publications with VIM and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >178 publications with VIM and Neurodegenerative Diseases
 Inflammation Antibodies  >53 publications with VIM and Inflammation
 Kidney Diseases Antibodies  >41 publications with VIM and Kidney Diseases
 Pain Antibodies  >37 publications with VIM and Pain
 Disease Models, Animal Antibodies  >36 publications with VIM and Disease Models, Animal
 Hemorrhage Antibodies  >34 publications with VIM and Hemorrhage
 Liver Diseases Antibodies  >34 publications with VIM and Liver Diseases
 Neoplasm Metastasis Antibodies  >32 publications with VIM and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >29 publications with VIM and Breast Neoplasms

Organs/Tissues associated with anti-VIM antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >505 publications with VIM and Brain
 Blood Antibodies  >217 publications with VIM and Blood
 Muscle Antibodies  >116 publications with VIM and Muscle
 Nerve Antibodies  >83 publications with VIM and Nerve
 Bone Antibodies  >77 publications with VIM and Bone
 Kidney Antibodies  >60 publications with VIM and Kidney
 Liver Antibodies  >58 publications with VIM and Liver
 Bone Marrow Antibodies  >52 publications with VIM and Bone Marrow
 Eye Antibodies  >48 publications with VIM and Eye
 Ganglia Antibodies  >41 publications with VIM and Ganglia
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