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Heat Shock Protein 27 (HSPB1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS225266

Rabbit anti Heat shock protein 27 (pSer82) antibody recognizes heat shock protein 27, also known as heat shock protein beta-1, estrogen-regulated 24 kDa protein or stress-responsive protein 27, when phosphorylated at serine 82.Heat shock protein 27 is a… More details

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Product Overview

Product Name
Heat Shock Protein 27 (HSPB1), Polyclonal Antibody
Full Product Name
Rabbit anti Heat Shock Protein 27 (pSer82)
Product Gene Name
anti-HSPB1 antibody
Product Synonym Names
Heat Shock Protein 27 (pSer82) Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat (Expected from Sequence)
Form/Format
Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.
Purity/Purification
Purified whole serum by affinity chromatography.
Preparation and Storage
Store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch
Molecular Weight
22,783 Da
OMIM
602195
3D Structure
ModBase 3D Structure for P04792
Immunogen
Phospho specific-peptide corresponding to residues surrounding serine 82 of human heat shock protein 27
Preperation
Antiserum to heat shock protein 27 (pSer82) was raised by repeated immunization of rabbits with highly purified antigen.
Applications Tested/Suitable for anti-HSPB1 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-HSPB1 antibody
IHC-Paraffin: 1:50-1:100
WB: 1:500-1:2000

Western Blot (WB) of anti-HSPB1 antibody

Western blot analysis of extracts from HL60 cells untreated or treated with UV (for 15-30 minutes) using Rabbit anti heat shock protein 27 (pSer82) antibody
Rabbit Anti-HSPB1 Polyclonal Antibody – Cat# MBS225266

Immunohistochemistry (IHC) of anti-HSPB1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Rabbit anti heat shock protein 27 (pSer82) antibody
Rabbit Anti-HSPB1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS225266

Other Notes

Small volumes of anti-HSPB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSPB1 purchase

MBS225266 is an antibody targeting HSPB1. Also known as Rabbit anti Heat Shock Protein 27 (pSer82). Reactive in Human, Rat (Expected from Sequence). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSPB1. It may not necessarily be applicable to this product.

NCBI GI #
19855073
NCBI GeneID
3315
NCBI Accession #
P04792.2
UniProt Primary Accession #
P04792
UniProt Secondary Accession #
Q6FI47; Q96C20; Q96EI7; Q9UC31; Q9UC34; Q9UC35; Q9UC36; B2R4N8
UniProt Related Accession #
P04792
NCBI Official Full Name
Heat shock protein beta-1
NCBI Official Synonym Full Names
heat shock protein family B (small) member 1
NCBI Official Symbol
HSPB1
NCBI Official Synonym Symbols
CMT2F; HMN2B; HSP27; HSP28; Hsp25; SRP27; HS.76067; HEL-S-102
UniProt Protein Name
Heat shock protein beta-1
UniProt Synonym Protein Names
28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27
Protein Family
Heat shock protein
UniProt Gene Name
HSPB1
UniProt Synonym Gene Names
HSP27; HSP28; HspB1; HSP 27; SRP27
NCBI Protein Information
heat shock protein beta-1

NCBI Summary for HSPB1

This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
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UniProt Comments for HSPB1

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742).
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Research Articles on HSPB1

1. HSP27 is an independent predictor of prognosis in chronic HF

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-HSPB1 antibody

 Products by Pathway  Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with anti-HSPB1 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >95 publications with HSPB1 and Disease Models, Animal
 Necrosis Antibodies  >70 publications with HSPB1 and Necrosis
 Inflammation Antibodies  >66 publications with HSPB1 and Inflammation
 Breast Neoplasms Antibodies  >62 publications with HSPB1 and Breast Neoplasms
 Heart Diseases Antibodies  >60 publications with HSPB1 and Heart Diseases
 Liver Diseases Antibodies  >42 publications with HSPB1 and Liver Diseases
 Reperfusion Injury Antibodies  >35 publications with HSPB1 and Reperfusion Injury
 Kidney Diseases Antibodies  >32 publications with HSPB1 and Kidney Diseases
 Lung Neoplasms Antibodies  >30 publications with HSPB1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >29 publications with HSPB1 and Neoplasms, Experimental

Organs/Tissues associated with anti-HSPB1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >229 publications with HSPB1 and Muscle
 Blood Antibodies  >156 publications with HSPB1 and Blood
 Brain Antibodies  >154 publications with HSPB1 and Brain
 Heart Antibodies  >115 publications with HSPB1 and Heart
 Nerve Antibodies  >109 publications with HSPB1 and Nerve
 Vascular Antibodies  >97 publications with HSPB1 and Vascular
 Liver Antibodies  >81 publications with HSPB1 and Liver
 Lung Antibodies  >72 publications with HSPB1 and Lung
 Kidney Antibodies  >72 publications with HSPB1 and Kidney
 Skin Antibodies  >44 publications with HSPB1 and Skin
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