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Manic Fringe (MFNG) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS225583

Rabbit anti Manic Fringe antibody recognizes beta-1,3-N-acetylglucosaminyltransferase manic fringe, also known as MFNG. It belongs to the beta3N-acteylglucosaminyl-transferases family that modulates the Notch signaling pathway activity (Haines and Irvine… More details

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Product Overview

Product Name
Manic Fringe (MFNG), Polyclonal Antibody
Full Product Name
Rabbit Anti Manic Fringe
Product Gene Name
Product Synonym Names
Manic Fringe antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid; 0.42% Potassium Phosphate 0.87% Sodium Chloride
Purity/Purification
Purified IgG was prepared from whole serum by affinity chromatography.
Preparation and Storage
Store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
Should this product contain a precipitate we recommend microcentrifugation before use.
OMIM
602577
3D Structure
ModBase 3D Structure for O00587
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Manic Fringe
Preservative Stabilizers
0.01% Sodium Azide (NaN3) 30% Glycerol
Applications Tested/Suitable for anti-MFNG antibody
Western Blot (WB)

Western Blot (WB) of anti-MFNG antibody

Western blot analysis of HepG2 cell lysate using Rabbit anti Manic Fringe antibody
Rabbit Anti-MFNG Polyclonal Antibody – Cat# MBS225583

Other Notes

Small volumes of anti-MFNG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MFNG purchase

MBS225583 is an antibody targeting MFNG. Also known as Rabbit Anti Manic Fringe. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MFNG. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform 2
NCBI Official Synonym Full Names
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
NCBI Official Symbol
MFNG
UniProt Protein Name
Beta-1,3-N-acetylglucosaminyltransferase manic fringe
UniProt Synonym Protein Names
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
UniProt Gene Name
MFNG
UniProt Entry Name
MFNG_HUMAN
NCBI Protein Information
beta-1,3-N-acetylglucosaminyltransferase manic fringe

NCBI Summary for MFNG

This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the LFNG (GeneID: 3955) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene may control Notch signaling in claudin-low breast cancer. [provided by RefSeq, May 2018]
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UniProt Comments for MFNG

MFNG: Glycosyltransferase involved in the elongation of O- linked ligands to activate Notch signaling. Possesses fucose- specific beta-1,3-N-acetylglucosaminyltransferase activity. Belongs to the glycosyltransferase 31 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Membrane protein, integral; EC 2.4.1.222

Chromosomal Location of Human Ortholog: 22q12

Cellular Component: extracellular space; integral to Golgi membrane

Molecular Function: metal ion binding; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

Biological Process: positive regulation of protein binding; metabolic process; pattern specification process; positive regulation of Notch signaling pathway
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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