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CD88 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS225643

Mouse anti Human CD88 antibody, clone P12/1 recognizes the C5a receptor (C5aR) also known as CD88 or C5a anaphylatoxin chemotactic receptor 1. CD88 is predominantly expressed on cells of the myeloid lineage.Mouse anti Human CD88 antibody, clone P12/1 does not… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD88, Monoclonal Antibody
Full Product Name
Mouse Anti Human CD88: RPE
Product Gene Name
anti-CD88 antibody
Product Synonym Names
CD88 antibody (P12/1); Mouse anti Human CD88
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
P12/1
Host
Mouse
Species Reactivity
Human, Rhesus Monkey
Form/Format
Liquid; Phosphate Buffered Saline
Purity/Purification
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody.
Should this product contain a precipitate we recommend microcentrifugation before use.
OMIM
113995
3D Structure
ModBase 3D Structure for P21730
Immunogen
C5aR-peptide: Met1-Asn31
Conjugation
RPE
Carrier Free
Yes
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse X63-Ag8 myeloma cell line.
Preservative Stabilizers
0.09% Sodium Azide
Applications Tested/Suitable for anti-CD88 antibody
Flow Cytometry (FC/FACS)

Testing Data of anti-CD88 antibody

Figure A. Alexa Fluor647 conjugated mouse anti human CD16 and RPE conjugated mouse IgG2a isotype control . Figure B. Alexa Fluor647 conjugated mouse anti human CD16 and RPE conjugated mouse anti human CD88 . All experiments performed on red cell lysed human blood gated on granulocytes in the presence of Human Seroblock (BUF070A). Data acquired on the ZE5 cell analyzer.
Mouse Anti-CD88 Monoclonal Antibody – Cat# MBS225643

Testing Data of anti-CD88 antibody

FFPE human spleen stained with Mouse Anti-Human CD88 , biotinylated Anti-Mouse IgG and Streptavidin Alkaline Phosphatase (red). Nuclei were counterstained with hematoxylin.
Mouse Anti-CD88 Monoclonal Antibody, Testing Data – Cat# MBS225643

Other Notes

Small volumes of anti-CD88 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD88 purchase

MBS225643 is an antibody targeting CD88. Also known as Mouse Anti Human CD88: RPE. Reactive in Human, Rhesus Monkey. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD88. It may not necessarily be applicable to this product.

NCBI GI #
4502509
NCBI GeneID
728
NCBI Accession #
NP_001727.1
UniProt Primary Accession #
P21730
UniProt Related Accession #
P21730
GenBank Nucleotide #
NM_001736.3
NCBI Official Full Name
C5a anaphylatoxin chemotactic receptor 1
NCBI Official Synonym Full Names
complement C5a receptor 1
NCBI Official Symbol
C5AR1
NCBI Official Synonym Symbols
C5A; C5AR; C5R1; CD88
UniProt Protein Name
C5a anaphylatoxin chemotactic receptor
UniProt Gene Name
C5AR1
UniProt Synonym Gene Names
C5AR; C5R1; C5a-R; C5aR
UniProt Entry Name
C5AR_HUMAN
NCBI Protein Information
C5a anaphylatoxin chemotactic receptor 1

UniProt Comments for CD88

C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: cell surface; basolateral plasma membrane; integral to plasma membrane; apical part of cell; cytoplasmic membrane-bound vesicle; plasma membrane

Molecular Function: complement component C5a receptor activity; complement component C5a binding; C5a anaphylatoxin receptor activity

Biological Process: neutrophil chemotaxis; organ regeneration; sensory perception of chemical stimulus; activation of MAPK activity; apoptosis; response to lipopolysaccharide; chemotaxis; cell proliferation in hindbrain; signal transduction; mRNA transcription from RNA polymerase II promoter; elevation of cytosolic calcium ion concentration; defense response to Gram-positive bacterium; phospholipase C activation; response to peptidoglycan; cellular defense response; immune response; negative regulation of neuron apoptosis; inflammatory response; positive regulation of epithelial cell proliferation
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Research Articles on CD88

1. Furthermore, Apigenin reduced the proliferation of human NPC cells triggered by C5a through negative regulation of C5aR/PCAF/STAT3 axis. These might provide a new insight into the function of Apigenin in cancer treatment, and also provide a potential strategy for treating human NPC through inhibition of C5aR expression on cancer cells
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD88 antibody

 Reference Product  PubMed Publications
 RPS19 antibody  >1 publications with CD88 and RPS19
 GNAI2 antibody  >1 publications with CD88 and GNAI2

Pathways associated with anti-CD88 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram

Diseases associated with anti-CD88 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >29 publications with CD88 and Inflammation
 Immune System Diseases Antibodies  >15 publications with CD88 and Immune System Diseases
 Cardiovascular Diseases Antibodies  >6 publications with CD88 and Cardiovascular Diseases
 Lung Diseases Antibodies  >5 publications with CD88 and Lung Diseases
 Lung Injury Antibodies  >3 publications with CD88 and Lung Injury
 Heart Diseases Antibodies  >3 publications with CD88 and Heart Diseases
 Necrosis Antibodies  >3 publications with CD88 and Necrosis
 Neoplasms Antibodies  >3 publications with CD88 and Neoplasms
 Shock, Septic Antibodies  >3 publications with CD88 and Shock, Septic
 Atherosclerosis Antibodies  >2 publications with CD88 and Atherosclerosis

Organs/Tissues associated with anti-CD88 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >38 publications with CD88 and Blood
 Bone Marrow Antibodies  >4 publications with CD88 and Bone Marrow
 Intestine Antibodies  >4 publications with CD88 and Intestine
 Placenta Antibodies  >2 publications with CD88 and Placenta
 Uterus Antibodies  >1 publications with CD88 and Uterus
 Prostate Antibodies  >1 publications with CD88 and Prostate
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