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CD230 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS225678

Mouse anti Sheep CD230 (Prpsc) antibody, clone ROS-BC6 recognizes the prion disease form of prion protein known as CD230. Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal infectious neurodegenerative diseases of humans and animals… More details

$460 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD230, Monoclonal Antibody
Full Product Name
Mouse Anti Sheep CD230 (aa144-154)
Product Gene Name
anti-CD230 antibody
Product Synonym Names
CD230 antibody (ROS-BC6)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
ROS-BC6
Host
Mouse
Species Reactivity
Sheep, Bovine, Hamster, Mouse, Red Deer
Does not react with: Human
Form/Format
Liquid; Phosphate Buffered Saline
Purity/Purification
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Concentration
1.0 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
3D Structure
ModBase 3D Structure for P23907
Immunogen
A truncated form of recombinant Ovine PRP spanning residues aa94-aa233.
Fusion Partners
Spleen cells from immunised 129/Ola mice were fused with cells of the SP2/0 myeloma cell line.
Preservative Stabilizers
0.09% Sodium Azide (NaN3)
Applications Tested/Suitable for anti-CD230 antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

Western Blot (WB) of anti-CD230 antibody

Western Blot analysis of various tissues using Mouse anti Sheep CD230, clone ROS-BC6 . Lane 1 PRPc BSE infected ovine medulla, Lane 2 PRPc uninfected ovine medulla, Lane 3 Scrapie infected ovine medulla, Lane 4 PRPsc scrapie infected ovine spleen, Lane 5 PRPsc BSE infected ovine medulla, Lane 6 PRPsc BSE infected ovine spleen. Image courtesy of The Roslin Institute
Mouse Anti-CD230 Monoclonal Antibody – Cat# MBS225678

Flow Cytometry (FC/FACS) of anti-CD230 antibody

Flow Cytometry analysis of CD230. Ovine PBMC's staining using Mouse anti Sheep CD230, clone ROS-BC6 as the primary antibody followed by an anti mouse IgG conjugated to APC. Gated on sytox blue negative live cells and the PBMC region determined by FSC v. SSC profile. Image courtesy of The Roslin Institute.
Mouse Anti-CD230 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS225678

Flow Cytometry (FC/FACS) of anti-CD230 antibody

Flow Cytometry analysis of ovine PBMC's using Mouse anti Sheep CD230, clone ROS-BC6 . Images courtesy of the Roslin Institute
Mouse Anti-CD230 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS225678

Other Notes

Small volumes of anti-CD230 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD230 purchase

MBS225678 is an antibody targeting CD230. Also known as Mouse Anti Sheep CD230 (aa144-154). Reactive in Sheep, Bovine, Hamster, Mouse, Red Deer
Does not react with: Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD230. It may not necessarily be applicable to this product.

NCBI GI #
57164159
NCBI GeneID
493887
NCBI Accession #
NP_001009481.1
UniProt Primary Accession #
P23907
UniProt Secondary Accession #
P10279
UniProt Related Accession #
P23907
GenBank Nucleotide #
NM_001009481.1
NCBI Official Full Name
major prion protein
NCBI Official Symbol
PRNP
NCBI Official Synonym Symbols
Prp; SIP; PRPC
UniProt Protein Name
Major prion protein
UniProt Synonym Protein Names
CD_antigen: CD230
Protein Family
Major prion protein
UniProt Gene Name
PRNP
UniProt Synonym Gene Names
PRP; SIP; PrP
UniProt Entry Name
PRIO_SHEEP
NCBI Protein Information
major prion protein

UniProt Comments for CD230

Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains ().
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Research Articles on CD230

1. To determine the relative amounts of PrP polymorphisms present in atypical scrapie, total PrP was digested with chymotrypsin to generate characteristic peptides spanning relevant polymorphisms at positions 136, 141, 154, 171, and 172 of sheep PrP(C). An atypical scrapie infection does not result from an overexpression of sheep PrP(C).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD230 antibody

 Products by Pathway  Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram

Diseases associated with anti-CD230 antibody

 Disease Name  Pubmed Publications
 Prion Diseases Antibodies  >1028 publications with CD230 and Prion Diseases
 Nervous System Diseases Antibodies  >1017 publications with CD230 and Nervous System Diseases
 Creutzfeldt-Jakob Syndrome Antibodies  >385 publications with CD230 and Creutzfeldt-Jakob Syndrome
 Scrapie Antibodies  >261 publications with CD230 and Scrapie
 Gerstmann-Straussler-Scheinker Disease Antibodies  >117 publications with CD230 and Gerstmann-Straussler-Scheinker Disease
 Alzheimer Disease Antibodies  >110 publications with CD230 and Alzheimer Disease
 Insomnia, Fatal Familial Antibodies  >98 publications with CD230 and Insomnia, Fatal Familial
 Disease Models, Animal Antibodies  >70 publications with CD230 and Disease Models, Animal
 Nerve Degeneration Antibodies  >27 publications with CD230 and Nerve Degeneration
 Inflammation Antibodies  >15 publications with CD230 and Inflammation

Organs/Tissues associated with anti-CD230 antibody

 Organ/Tissue Name  Pubmed Publications
 Digestive Antibodies  >40 publications with CD230 and Digestive
 Lymphoreticular Antibodies  >21 publications with CD230 and Lymphoreticular
 Bone Antibodies  >18 publications with CD230 and Bone
 Skin Antibodies  >5 publications with CD230 and Skin
 Mammary Gland Antibodies  >3 publications with CD230 and Mammary Gland
 Hindlimb Antibodies  >1 publications with CD230 and Hindlimb
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