CD164 Antibody – Mouse Monoclonal

Mouse anti Human CD164 clone 67D2, recognizes CD164, also known as endolyn, a 160 kDa transmembrne homodimer protein. It is composed of an extracellular region and two O-glycosylated mucin domains (I and II). These two domains are linked by a non-mucin cysteine rich subdomain.
CD164 is a member of the sialmucin family and is expressed by CD34+ hematopoietic progenitor cells, activated basophils, erythroid cells as well as various cancerous cells. A key role of CD164 is its involvement in regulating adhesion, migration and proliferation of hematopoietic progenitor cells (Zannettino et al. 1998).
Elevated expression of CD164 has been observed in patients with Seazy syndrome which is a primary cutaneous T-cell lymphoma and as such, has been suggested as a potential marker of this disease (Guenova et al. 2016).
This clone CD67D2 recognizes the class II epitope which is not sensitive to sialidase, N-glycanase and O-sialglycoprotease of CD164. This clones has been used in flow cytometry to examine CD164 upregulation in CD203c+ activated basophils (Hennersdorf et al. 2005).

Small volumes of anti-CD164 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS225764 is an antibody targeting CD164. Also known as Mouse Anti Human CD164. Reactive in Human. Host: Mouse.