CD163 Antibody – Mouse Monoclonal

Mouse anti Human CD163 antibody, clone EDHu-1 recognizes the human CD163 cell surface antigen, a 130-140 kDa glycoprotein expressed by tissue macrophages. CD163 expression may be induced on monocytes by culture in dexamethasone.
Clone EDHu-1 is reported to inhibit the binding of haptoglobin/hemoglobin to CD163 (Madsen et al. 2004).Truncation mutation analysis demonstrates binding of EDHu-1 occurs via the N-terminal region of CD163 containing the first three scavenger receptor, Cysteine-rich, SRCR domains the third domain being critical as, cleavage of this domain at the major cleavage site ASP-265 abrogates binding to the N-terminal fragment.

1. Kristiansen, M. et al. (2001) Identification of the haemoglobin scavenger receptor.Nature. 409 (6817): 198-201.
2. Madsen, M. et al. (2004) Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region.J Biol Chem. 279 (49): 51561-7.
3. Kim, W.K. et al. (2006) CD163 identifies perivascular macrophages in normal and viral encephalitic brains and potential precursors to perivascular macrophages in blood.Am J Pathol. 168 (3): 822-34.
4. Moreno JA et al. (2010) Peripheral artery disease is associated with a high CD163/TWEAK plasma ratio.Arterioscler Thromb Vasc Biol. 30 (6): 1253-62.
5. Herrmann-Hoesing, L.M. (2010) Ovine progressive pneumonia virus capsid antigen as found in CD163- and CD172a-positive alveolar macrophages of persistently infected sheep.Vet Pathol. 47: 518-28.

Small volumes of anti-CD163 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS225948 is an antibody targeting CD163. Also known as MOUSE ANTI HUMAN CD163: FITC. Reactive in Human. Host: Mouse.