ARRESTIN 1/2 (BETA) Antibody – Mouse Monoclonal

Mouse anti beta arrestin-11 antibody, clone 21-B1 recognises beta arrestin-1 and beta arrestin-2, members of the arrestin family, originally characterised as proteins involved in mediating the desensitization of G protein-coupled receptors (GPCR) by endocytosis. Beta arrestin 2 may also play a role in the down-regulation of TGF- beta receptor signalling. In addition, beta arrestins may also be involved in chemotaxis, cellular migration and metastasis.
In quiescent cells, beta arrestin is mainly located in the cytosol but translocates to the membrane as a result of GPCR receptor phosphorylation.

1. Hüttenrauch, F. et al. (2005) G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.J Biol Chem. 280 (45): 37503-15.
2. Ogasawara, F. et al. (2016) Concurrent Fowlpox and Candidiasis Diseases in Backyard Chickens with Unusual Pox Lesions in the Bursa of Fabricius.Avian Dis. 60 (3): 705-8.

Small volumes of anti-BETA ARRESTIN 1/2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS225970 is an antibody targeting BETA ARRESTIN 1/2. Also known as MOUSE ANTI BETA ARRESTIN 1/2. Reactive in Synthetic Peptide. Host: Mouse.