Interleukin 27 ALPHA (IL-27 ALPHA) Antibody – Mouse Monoclonal

Mouse anti Human IL-27alpha, clone H08-5C8, recognizes IL-27alpha, a subunit of IL-27. IL-27 is a 62 kDa member of the Il-6/IL-12 family of long type I cytokines. IL-27 is heterodimeric group 2 receptor composed of Epstein-Barr Virus induced gene 3 (EBI3) and IL-27alpha. EBI3 is a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23 and IL-27alpha is a 28 kDa glycoprotein that is related to the p35 of chain IL-12.
IL-27 has broad range of pro- and anti-inflammatory properties, mediating its effects via its gp130-associated cytokine receptor and JAK/STAT signalling cascades. It can alter T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells and has diverse effects on innate immune cells. In vivo, it is reported to play an important role in immune regulation, as mice with defects in IL-27 or its receptor display enhanced immune responses (Batten & Ghilardi 2007).

1. Batten, M. & Ghilardi, N. (2007) The biology and therapeutic potential of interleukin 27J Mol Med (Berl). 85: 661-72.

Small volumes of anti-IL-27 Alpha antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS226014 is an antibody targeting IL-27 Alpha. Also known as MOUSE ANTI HUMAN INTERLEUKIN 27 ALPHA. Reactive in Human. Host: Mouse.