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Follicle Stimulating Hormone (FSH) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142647

FSH Human Recombinant produced in HEK-293 cells is heterodimeric, glycosylated, polypeptide chain transfected with two expression plasmids encoding the human FSH-alpha chain (Accession # P01215) (Met1-Ser116) and human FSH-beta chain(Accession # P01225)… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Follicle Stimulating Hormone (FSH), Active Protein
Full Product Name
Recombinant Human Follicle Stimulating Hormone
Product Gene Name
FSH active protein
Product Synonym Names
FSH Human; Follicle Stimulating Hormone Human Recombinant; Follitropin subunit beta; Follicle-stimulating hormone beta subunit; FSH-beta; FSH-B; Follitropin beta chain; FSH
Sequence
FSH subunit alpha: APDVQDCPEC TLQENPFFSQ PGAPILQCMG CCFSRAYPTP LRSKKTMLVQ KNVTSESTCC VAKSYNRVTV MGGFKVENHT ACHCSTCYYH KS.
FSH subunit beta: NSCELTNITI AIEKEECRFC ISINTTWCAG YCYTRDLVYK DPARPKIQKT CTFKELVYET VRVPGCAHHA DSLYTYPVAT QCHCGKCDSD STDCTVRGLG PSYCSFGEMK E
Host
HEK293
Form/Format
The recombinant FSH was lyophilized from 0.2um filtered solution containing PBS, pH 7.4.
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Preparation and Storage
Lyophilized FSH although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FSH should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
OMIM
136530
3D Structure
ModBase 3D Structure for P01225
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility
It is recommended to reconstitute the lyophilized Follicle Stimulating Hormone in sterile 18MΩ-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The ED50 as determined by cAMP accumulation in human FSH Receptor transfected Chinese Hamster Ovary cells was found to be 80-450 pg/ml.

Product Categories/Family for FSH active protein

Hormones; Hormones; FSH

Other Notes

Small volumes of FSH active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FSH purchase

MBS142647 is an active protein targeting FSH. Also known as Recombinant Human Follicle Stimulating Hormone. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for FSH. It may not necessarily be applicable to this product.

NCBI GI #
4503791
NCBI GeneID
2488
NCBI Accession #
NP_000501.1
UniProt Primary Accession #
P01225
UniProt Secondary Accession #
Q14D61; A2TF08; A5JVV3
UniProt Related Accession #
P01225
GenBank Nucleotide #
NM_000510.2
NCBI Official Full Name
follitropin subunit beta
NCBI Official Synonym Full Names
follicle stimulating hormone, beta polypeptide
NCBI Official Symbol
FSHB
UniProt Protein Name
Follitropin subunit beta
UniProt Synonym Protein Names
Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain
Protein Family
Follicle-stimulating hormone receptor
UniProt Gene Name
FSHB
UniProt Synonym Gene Names
FSH-B; FSH-beta
UniProt Entry Name
FSHB_HUMAN
NCBI Protein Information
follitropin subunit beta; FSH-B; FSH-beta; follicle-stimulating hormone beta subunit; follitropin beta chain; follitropin, beta chain

NCBI Summary for FSH

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
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UniProt Comments for FSH

FSHB: Stimulates development of follicle and spermatogenesis in the reproductive organs. Defects in FSHB are a cause of isolated follicle- stimulating hormone deficiency (IFSHD). Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. Belongs to the glycoprotein hormones subunit beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: cytoplasm; extracellular region

Molecular Function: follicle-stimulating hormone activity; protein binding; hormone activity

Biological Process: progesterone biosynthetic process; follicle-stimulating hormone signaling pathway; peptide hormone processing; female gamete generation; Sertoli cell proliferation; female pregnancy; signal transduction; cellular protein metabolic process; regulation of osteoclast differentiation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of bone resorption; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell migration

Disease: Follicle-stimulating Hormone Deficiency, Isolated
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Research Articles on FSH

1. The combined effect of FSHB GG+FSHR AA may potentiate the FSH pathway, which increases serum levels of FSH and reduces antimullerian hormone in health girls.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FSH active protein

 Reference Product  PubMed Publications
 FSHR active protein  >27 publications with FSH and FSHR
 CGA active protein  >27 publications with FSH and CGA
 GNRHR active protein  >16 publications with FSH and GNRHR
 GNRH1 active protein  >7 publications with FSH and GNRH1
 BMP2 active protein  >5 publications with FSH and BMP2
 INHA active protein  >4 publications with FSH and INHA
 INHBB active protein  >3 publications with FSH and INHBB
 INHBA active protein  >1 publications with FSH and INHBA

Pathways associated with FSH active protein

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Glycoprotein Hormones Pathway antibodies  Glycoprotein Hormones Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram

Diseases associated with FSH active protein

 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >16 publications with FSH and Infertility, Male
 Kidney Diseases Antibodies  >10 publications with FSH and Kidney Diseases
 Infertility, Female Antibodies  >10 publications with FSH and Infertility, Female
 Hypogonadism Antibodies  >6 publications with FSH and Hypogonadism
 Nervous System Diseases Antibodies  >4 publications with FSH and Nervous System Diseases
 Weight Gain Antibodies  >1 publications with FSH and Weight Gain
 Breast Neoplasms Antibodies  >1 publications with FSH and Breast Neoplasms
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with FSH and Prenatal Exposure Delayed Effects
 Follicle-stimulating hormone deficiency, isolated Antibodies  >1 publications with FSH and Follicle-stimulating hormone deficiency, isolated
 Amenorrhea Antibodies  >1 publications with FSH and Amenorrhea

Organs/Tissues associated with FSH active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >79 publications with FSH and Brain
 Pituitary Gland Antibodies  >72 publications with FSH and Pituitary Gland
 Testis Antibodies  >24 publications with FSH and Testis
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